Serum amyloid A is a useful marker to evaluate the disease activity of Takayasu's arteritis
Serum amyloid A is a useful marker to evaluate the disease activity of Takayasu's arteritis
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DOI：
10.1007/s00296-009-1296-6
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发表时间：
2010-02-01
影响因子：
4
通讯作者：
Migita, Kiysohi
中科院分区：
文献类型：
--
作者：
Koga, Tomohiro;Nishino, Yuichiro;Migita, Kiysohi
大动脉炎(TA)是一种罕见的大血管血管炎，早期诊断困难。因此，TA不可逆性血管损伤的管理和预防也是非常困难的。使用[F-18]-FDG-PET检查了一名19岁的女性背痛患者，以检测炎症的来源。在胸主动脉和腹主动脉可观察到[F-18]-FDG的特异性积聚，从而诊断为TA。皮质类固醇治疗导致临床缓解。然而，血清淀粉样蛋白A(SAA)水平仍然很高。后续扫描显示胸主动脉残余摄取[F-18]-FDG，提示亚临床血管炎症。甲氨蝶呤与皮质类固醇联合使用，升高的SAA水平变得正常。本病例提示监测血清SAA和[F-18]-FDG-PET水平可帮助临床医生对TA患者进行适当的治疗调整。
Takayasu's arteritis (TA) is a rare large vessel vasculitis that is difficult to diagnose in the early stages. Therefore, it is also very difficult to manage and prevent irreversible vascular damage in TA. A 19-year-old female patient with back pain was examined using [F-18]-FDG-PET to detect the source of inflammation. Specific accumulation of [F-18]-FDG was observed in the thoracic and abdominal aorta, leading to the diagnosis of TA. Corticosteroid treatment resulted in clinical remission. However, the serum amyloid A (SAA) levels remained elevated. A follow-up scan showed residual uptake of [F-18]-FDG in the thoracic aorta suggesting subclinical vascular inflammation. Methotrexate was combined with the corticosteroid, and the elevated levels of SAA became normalized. The present case suggests that monitoring serum levels of SAA and [F-18]-FDG-PET could help clinicians to make adequate treatment adjustments in TA patients.