Reality monitoring impairment in schizophrenia reflects specific prefrontal cortex dysfunction.
Reality monitoring impairment in schizophrenia reflects specific prefrontal cortex dysfunction.
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DOI：
10.1016/j.nicl.2017.01.028
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Simons JS
中科院分区：
文献类型：
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作者：
Garrison JR;Fernandez-Egea E;Zaman R;Agius M;Simons JS
精神分裂症中经常报告现实监测障碍，但这种缺陷的神经基础知之甚少。现实监测的困难可能是由于神经功能障碍的模式与精神分裂症的其他认知缺陷相同，或者可能是一种可分离和可分离的损害。通过直接比较精神分裂症患者和匹配的健康对照者的行为表现和与现实监测和工作记忆相关的神经活动来解决这个问题。受试者在接受功能磁共振成像扫描的同时，完成了一个词对现实监测任务和一个斯滕贝格工作记忆任务。在每个任务的执行过程中，观察到不同的行为缺陷的患者，这与可分离的任务和区域特定的功能障碍，在内侧前额叶皮层的现实监测和背外侧前额叶皮层的工作记忆。结果表明，现实监测障碍是一个独特的神经认知功能障碍的精神分裂症。这些发现与精神分裂症中存在一系列可分离的认知缺陷是一致的，这些认知缺陷可能与潜在处理网络中的可变功能和结构性连接障碍有关。我们研究了精神分裂症患者的现实监控和工作记忆。在每项任务的执行过程中观察到不同的行为缺陷在不同的前额叶皮层区域可分离的任务和区域特异性功能障碍现实监测似乎是精神分裂症中一种独特的神经认知缺陷。
Reality monitoring impairment is often reported in schizophrenia but the neural basis of this deficit is poorly understood. Difficulties with reality monitoring could be attributable to the same pattern of neural dysfunction as other cognitive deficits that characterize schizophrenia, or might instead represent a separable and dissociable impairment. This question was addressed through direct comparison of behavioral performance and neural activity associated with reality monitoring and working memory in patients with schizophrenia and matched healthy controls. Participants performed a word-pair reality monitoring task and a Sternberg working memory task while undergoing fMRI scanning. Distinct behavioral deficits were observed in the patients during performance of each task, which were associated with separable task- and region-specific dysfunction in the medial anterior prefrontal cortex for reality monitoring and dorsolateral prefrontal cortex for working memory. The results suggest that reality monitoring impairment is a distinct neurocognitive deficit in schizophrenia. The findings are consistent with the presence of a range of dissociable cognitive deficits in schizophrenia which may be associated with variable functional and structural dysconnectivity in underlying processing networks. We examined reality monitoring and working memory in patients with schizophrenia. Distinct behavioral deficits observed during performance of each task Separable task- and region-specific dysfunction in distinct prefrontal cortex regions Reality monitoring appears to be a distinct neurocognitive deficit in schizophrenia.