ENHANCED INSULIN SECRETORY RESPONSE TO ACETYLCHOLINE BY PERIFUSED PANCREAS OF 5-DAY-OLD PREOBESE ZUCKER RATS
ENHANCED INSULIN SECRETORY RESPONSE TO ACETYLCHOLINE BY PERIFUSED PANCREAS OF 5-DAY-OLD PREOBESE ZUCKER RATS
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DOI：
10.1210/endo-129-4-2219
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发表时间：
1991-10-01
期刊：
影响因子：
4.8
通讯作者：
PENICAUD, L
中科院分区：
文献类型：
--
作者：
ATEF, N;BRULE, C;PENICAUD, L
在 5 日龄瘦 (Fa/Fa) 和肥胖前 (fa/fa) Zucker 大鼠的灌注胰腺中研究了对不同促分泌剂和神经递质的胰岛素分泌率。 单独的葡萄糖 (16.6 mM) 或与 20 mM 精氨酸或 5 mM 茶碱组合可诱导胰岛素分泌的净刺激。 两组的这种效果相似。 相比之下，乙酰胆碱对葡萄糖诱导的胰岛素分泌的刺激作用在肥胖前的幼鼠中明显高于瘦大鼠。 肥胖前期大鼠的去甲肾上腺素对胰岛素分泌的抑制作用也有比瘦大鼠更高的趋势，但这种差异并未达到统计学显着性。 这些结果共同表明，肥胖前 fa/fa 大鼠对营养促分泌剂的胰岛素分泌正常，但乙酰胆碱的作用增强。 后一种效应可能与自主神经系统活动的变化有关，这通常在肥胖 fa/fa 大鼠中描述。
The insulin secretion rate in response to different secretagogues and neurotransmittors was studied in perifused pancreases of 5-day-old lean (Fa/Fa) and preobese (fa/fa) Zucker rats. Glucose (16.6 mM) alone or in combination with 20 mM arginine or 5 mM theophylline induced a net stimulation of insulin secretion. This effect was similar in the two groups. By contrast, the stimulatory effect of acetylcholine on glucose-induced insulin secretion was significantly higher in preobese pups than in lean rats. There was also a tendency toward a higher inhibitory effect of norepinephrine on insulin secretion in preobese than in lean rats, but this difference did not reach statistical significance. Together these results demonstrate a normal insulin secretion in response to nutrient secretagogues in preobese fa/fa rats but an enhanced effect of acetylcholine. This latter effect may be related to the changes in the autonomic nervous system activity, which is usually described in obese fa/fa rats.