PRELIMINARY-REPORT - ACTIVATION OF THE CEREBELLUM IN ESSENTIAL TREMOR
PRELIMINARY-REPORT - ACTIVATION OF THE CEREBELLUM IN ESSENTIAL TREMOR
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DOI：
10.1016/0140-6736(90)92489-5
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发表时间：
1990-10-27
期刊：
影响因子：
168.9
通讯作者：
BROOKS, DJ
中科院分区：
文献类型：
--
作者：
COLEBATCH, JG;FINDLEY, LJ;BROOKS, DJ
在4例原发性震颤患者和4例正常对照者中，用正电子发射断层扫描仪记录了吸入15碳标记的二氧化碳过程中的脑血流图像。特发性震颤患者单侧不自主姿势性震颤与对侧感觉运动皮层、两侧运动前区和两侧小脑半球的血流显著大于静息时的血流相关。在这些区域中，在保持无震颤姿势的正常对照组或进行被动手腕运动的特发性震颤患者中，只有小脑没有被激活。因此，小脑中增加的流量似乎代表了与震颤产生有关的神经活动。有人提出，特发性震颤是由于小脑橄榄通路内的振荡，通过丘脑和运动皮层传递到脊髓。
Several images of cerebral blood flow were recorded during inhalation of carbon-15-labelled carbon dioxide by positron emission tomography in four patients with essential tremor and four normal controls. Unilateral involuntary postural tremor in essential tremor patients was associated with blood flow significantly greater than that at rest in the contralateral sensorimotor cortex, both lateral premotor regions, and both cerebellar hemispheres. Of these regions, only the cerebellum was not activated in normal controls holding a posture without tremor or in essential tremor patients undergoing passive wrist movement. The increased flow in the cerebellum therefore seems to represent neural activity involved in tremor generation. It is proposed that essential tremor is due to oscillation within cerebello-olivary pathways, relayed by way of thalamus and motor cortex to the spinal cord.