An evolutionary perspective on zinc uptake by human fungal pathogens
An evolutionary perspective on zinc uptake by human fungal pathogens
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DOI：
10.1039/c4mt00331d
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发表时间：
2015-01-01
期刊：
影响因子：
3.4
通讯作者：
Wilson, Duncan
中科院分区：
文献类型：
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作者：
Wilson, Duncan
哺乳动物的免疫系统已经进化出复杂的机制，以阻止必要的微量营养素入侵病原体。这些过程统称为营养免疫，用于限制微生物的增殖并促进对入侵者的杀戮。因此，成功的病原体已经制定了策略，以在受感染宿主的限制性环境中抵消营养免疫并获得必要的微量营养素。在这里，我利用现在大量的已测序的真菌基因组来探索人类真菌病原体获取锌的策略，并反思这些吸收途径的进化背景。
The mammalian immune system has evolved sophisticated mechanisms to withhold essential micronutrients from invading pathogens. These processes, collectively known as nutritional immunity serve to limit microbial proliferation and bolster killing of the invader. Successful pathogens, therefore, have developed strategies to counteract nutritional immunity and acquire essential micronutrients in the restrictive environment of the infected host. Here I take advantage of the now large number of sequenced fungal genomes to explore the zinc acquisition strategies of human fungal pathogens and reflect on the evolutionary context of these uptake pathways.