Kinetics of antibody responses in Rickettsia africae and Rickettsia conorii infections
Kinetics of antibody responses in Rickettsia africae and Rickettsia conorii infections
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DOI：
10.1128/cdli.9.2.324-328.2002
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发表时间：
2002-03-01
期刊：
影响因子：
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通讯作者：
Raoult, D
中科院分区：
文献类型：
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作者：
Fournier, PE;Jensenius, M;Raoult, D
由非洲立克次体引起的非洲蜱叮咬热是撒哈拉以南非洲最常见的蜱传立克次体病。由立克次体引起的地中海斑疹热也发生在该地区，但在地中海国家更为普遍。使用微量免疫荧光，我们比较了48例非洲蜱叮咬热和48例地中海斑点热患者的免疫球蛋白G（IgG）和IgM滴度的发展。在发病后7天内给予强力霉素治疗，可显著预防R抗体的产生。非洲。在非洲蜱叮咬热患者中，IgG和IgM血清转化的中位时间分别为症状发作后28天和25天。与地中海斑点热患者的血清转换时间相比，IgG的中位数为6天，IgM的中位数为9天（P < 10（-2））。我们建议在疑似非洲蜱叮咬热患者出现症状后4周采集血清，用于确定性血清学诊断。非洲感染。
African tick-bite fever, caused by Rickettsia africae, is the most common tick-borne rickettsiosis in sub-Saharan Africa. Mediterranean spotted fever due to Rickettsia conorii also occurs in the region but is more prevalent in Mediterranean countries. Using microimmunofluorescence, we compared the development of immunoglobulin G (IgG) and IgM titers in 48 patients with African tick-bite fever and 48 patients with Mediterranean spotted fever. Doxycycline treatment within 7 days from the onset of disease significantly prevented the development of antibodies to R. africae. In patients with African tick-bite fever, the median times to seroconversion with IgG and IgM were 28 and 25 days, respectively, after the onset of symptoms. These were significantly longer by a median of 6 days for IgG and 9 days for IgM than the times for seroconversion in patients with Mediterranean spotted fever (P < 10(-2)). We recommend that sera collected 4 weeks after the onset of signs of patients with suspected African tick-bite fever should be used for the definitive serological diagnosis of R. africae infections.