Dietary fat, fiber, and carbohydrate intake in relation to risk of endometrial cancer.
Dietary fat, fiber, and carbohydrate intake in relation to risk of endometrial cancer.
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DOI：
10.1158/1055-9965.epi-10-1089
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Hankinson SE
中科院分区：
文献类型：
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作者：
Cui X;Rosner B;Willett WC;Hankinson SE
脂肪和纤维等常量营养素被认为在子宫内膜癌的病因中发挥了作用。为了调查这些关联，作者分析了护士健康研究(NHS)的数据。从1980年到2006年，在130万人年的随访中，发现了669例侵袭性腺癌病例。1980年对膳食摄入量进行了评估，每2-4年更新一次。COX比例风险模型用于计算相对危险度(RR)，控制总能量和其他危险因素。总体而言，作者发现大多数饮食因素与子宫内膜癌风险之间没有显著关联。总脂肪与边缘显著降低的风险相关(上与下五分位数RR=0.78；95%可信区间[CI]=0.60，0.99；P趋势=0.18)。动物脂肪的研究结果与此类似。没有观察到膳食纤维与癌症风险之间的负相关。谷类纤维与风险呈中度正相关(上五分之一RR=1.38，95%CI=1.07，1.79；P趋势=0.05)。在绝经前妇女中观察到与动物脂肪摄入量呈负相关，与碳水化合物摄入量呈正相关，但在绝经后妇女中未观察到。在这项大型前瞻性研究中，没有观察到膳食脂肪、纤维或碳水化合物与子宫内膜癌风险之间的总体关联，尽管其中一些关系可能因绝经状态而异。总体来说，膳食脂肪和纤维摄入量似乎不是子宫内膜癌病因中的主要因素。然而，需要进一步评估这些相关性，特别是在绝经前妇女中。
Macronutrients such as fat and fiber have been hypothesized to play a role in the etiology of endometrial cancer. To investigate these associations, the authors analyzed data from the Nurses’ Health Study (NHS). From 1980 to 2006, 669 invasive adenocarcinoma cases were identified over 1.3 million person-years of follow-up. Dietary intake was assessed in 1980 and updated every 2–4 years. Cox proportional hazard models were used to calculate relative risks (RRs), controlling for total energy and other risk factors. Overall, the authors found no significant associations between most dietary factors and endometrial cancer risk. Total fat was associated with a borderline significant decreased risk (top vs. bottom quintile RR=0.78; 95% confidence interval [CI]=0.60, 0.99; Ptrend=0.18). Findings for animal fat were similar. No inverse associations between dietary fibers and cancer risk were observed. Cereal fiber was modestly positively associated with risk (top vs. bottom quintile RR=1.38, 95%CI=1.07, 1.79; Ptrend = 0.05). The inverse association with animal fat intake and a positive association with carbohydrate intake were observed among premenopausal but not among postmenopausal women. In this large prospective study, no overall association was observed between dietary fat, fiber, or carbohydrates with endometrial cancer risk, although several of the relationships may vary by menopausal status. Dietary fat and fiber intake do not appear to play a major role in endometrial cancer etiology overall. However, further evaluation of these associations, particularly in premenopausal women, is needed.