Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats
Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats
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发表时间：
2011-03
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通讯作者：
Zhongzhi Wang;J. Hasegawa;Xinhui Wang;A. Matsuda;T. Tokuda;N. Miura;Tatsuo Watanabe
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作者：
Zhongzhi Wang;J. Hasegawa;Xinhui Wang;A. Matsuda;T. Tokuda;N. Miura;Tatsuo Watanabe
本研究旨在探讨生姜对阿司匹林所致大鼠胃粘膜损伤的保护作用及其机制。通过对幽门结扎的雄性Wistar大鼠经口给予200 mg/kg阿司匹林混悬于1%羧甲基纤维素溶液中，造成胃粘膜损伤。生姜粉（200 mg/kg）可显著减少阿司匹林引起的胃出血性溃疡面积。阿司匹林和生姜对胃液总酸度无明显影响。生姜粉不影响阿司匹林诱导的粘膜前列腺素E2（PGE 2）含量的降低;但是，它确实改善了阿司匹林诱导的粘膜诱导型NO合酶（iNOS）活性和血浆肿瘤坏死因子（TNF）-α和白细胞介素（IL）-1β水平的升高。在接下来的实验中，在相同的实验模型中使用高剂量和低剂量的6-姜辣素和6-姜烯酚代替生姜粉，以检查它们在生姜抗溃疡机制中的作用。6-姜辣素和6-姜烯酚均降低阿司匹林诱导的溃疡形成、粘膜iNOS和血浆TNF-α和IL-1β水平。总之，生姜粉通过降低粘膜iNOS活性和炎性细胞因子的血浆水平来防止阿司匹林诱导的胃溃疡形成，但不影响胃液或胃酸产生或粘膜PGE 2含量。生姜粉对胃溃疡的这种保护作用可能归因于姜辣素和姜烯酚。
We investigated the mechanism underlying the protective effects of ginger against gastric damage induced by aspirin in rats. Gastric mucosal lesions were produced by orally administering 200 mg/kg aspirin suspended in 1% carboxymethylcellulose solution to pyloric-ligated male Wistar rats. Ginger powder (200 mg/kg) markedly reduced the aspirin-induced gastric hemorrhagic ulcer area. The total acidity of gastric juice was not significantly influenced by aspirin or ginger. Ginger powder did not affect the aspirin-induced reduction in mucosal prostaglandin E2 (PGE2) content; however, it did ameliorate the aspirin-induced increases in mucosal activity of the inducible form of NO synthase (iNOS) and plasma tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels. In the next experiment, high and low doses of 6-gingerol and 6-shogaol were used instead of ginger powder in the same experimental model to examine their roles in the anti-ulcer mechanism of ginger. Both 6-gingerol and 6-shogaol reduced aspirin induced ulcer formation, mucosal iNOS and plasma TNF-α and IL-1β levels. In conclusion, ginger powder prevents the aspirin induced gastric ulcer formation by reducing mucosal iNOS activity and the plasma levels of inflammatory cytokines but does not affect gastric juice or acid production or mucosal PGE2 content. This protective effect of ginger powder against gastric ulcers may be attributable to both gingerol and shogaol.