Controlled bacteriostasis of tea polyphenol loaded ultrahigh molecular weight polyethylene with high crosslink density and oxidation resistance for total joint replacement
Controlled bacteriostasis of tea polyphenol loaded ultrahigh molecular weight polyethylene with high crosslink density and oxidation resistance for total joint replacement
复制标题
用于全关节置换的高交联密度和抗氧化性的茶多酚负载超高分子量聚乙烯的受控抑菌
DOI：
10.1016/j.msec.2021.112040
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Li Zhong-Ming
中科院分区：
文献类型：
--
作者：
Wang Fei-Yu;Ren Yue;Lan Ri-Tong;Fu Wan-Qun;Chen Zi-Jian;Huang Shishu;Gul Rizwan M.;Wang Jing;Xu Jia-Zhuang;Li Zhong-Ming
To avoid catastrophic bacterial infection in prosthesis failure, ultrahigh molecular weight polyethylene (UHMWPE), a common bearing material of artificial joints, has been formulated with antibiotics to eliminate bacteria locally at the implant site. However, the pressing issues regarding cytotoxic effects and evolution of drug resistant bacteria necessitates the development of bio-friendly bacteriostat with long bacteriostatic efficacy. Herein, tea polyphenol extracted from nature source was introduced in UHMWPE as a biogenic antimicrobial. Controlled antimicrobial activity was achieved by chemical crosslinking to regulate the release of the tea polyphenol. In addition, the crosslinking efficiency of UHMWPE blends with high loaded tea polyphenol was significantly improved in comparison to radiation crosslinking. The immobilized tea polyphenols also enhanced the oxidation stability of the UHMWPE, which is essential to prolong the service life in vivo and the storage time in vitro. The blends presented good biocompatibility, despite cell repellent on the highly crosslinked surface. Chemically crosslinked tea polyphenol/UHMWPE exhibited feasible properties for total joint implants, which is promising for clinical application.
