Dopamine D3 receptor knock-out mice display deficits in locomotor sensitization after chronic morphine administration
Dopamine D3 receptor knock-out mice display deficits in locomotor sensitization after chronic morphine administration
复制标题
多巴胺 D3 受体敲除小鼠在长期服用吗啡后表现出运动敏化缺陷
DOI：
10.1016/j.neulet.2010.09.025
复制
发表时间：
2010-11-26
影响因子：
2.5
通讯作者：
Li, Sheng-bing
中科院分区：
文献类型：
--
作者：
Li, Tao;Hou, Ying;Li, Sheng-bing
运动敏感化是指药物等刺激物对啮齿动物运动的持续、渐进的增强作用。据报道，多巴胺D3受体在吗啡成瘾中起作用。本研究旨在探讨多巴胺D3受体在吗啡诱导的小鼠运动敏感化中的作用。多巴胺D3受体基因敲除小鼠没有表现出对急性吗啡注射的增强行为反应，也没有表现出对间歇注射吗啡的运动敏感率增加。纳洛酮2 mg/kg与吗啡10 mg/kg合用可显著阻断吗啡诱导的野生型小鼠的运动敏感化，而D3受体基因敲除小鼠的运动敏感度降低。然后给野生型小鼠注射多巴胺D3拮抗剂那法多曲德。结果表明，吗啡与那法曲德合用可有效抑制吗啡诱导的行为敏化程度。结论：多巴胺D3受体基因缺失可抑制急性吗啡诱导的多动活动和慢性吗啡诱导的行为敏化。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。
Locomotor sensitization is the progressive and enduring enhancement of locomotion induced by stimulants such as drugs, which alter rodent locomotion in a long-standing manner. The dopamine D3 receptor has been reported to play a role in morphine addiction. The aim of the present study was to investigate the role of dopamine D3 receptor in the morphine induced locomotor sensitization using dopamine D3 receptor knock-out mice. The dopamine D3 receptor knock-out mice did not display an enhanced behavioral response to acute morphine administration or develop an increased rate of locomotor sensitization to intermittent morphine administration. When 2 mg/kg naloxone was co-administered with 10 mg/kg morphine, morphine-induced locomotion sensitization in wild-type mice was significantly blocked while the locomotion in the D3 receptor knock-out mice was decreased. Then the wild-type mice were administered with dopamine D3 antagonist nafadotride. It was found that co-administration of morphine with nafadotride could effectively suppress the level of morphine induced behavioral sensitization. It was concluded that a loss of the dopamine D3 receptor gene may inhibit acute morphine induced hyperlocomotor activity and chronic morphine induced behavioral sensitization. (C) 2010 Elsevier Ireland Ltd. All rights reserved.