Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals - A randomized controlled trial
Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals - A randomized controlled trial
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DOI：
10.1001/jama.295.13.1539
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发表时间：
2006-04-05
影响因子：
120.7
通讯作者：
Ravussin, E
中科院分区：
文献类型：
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作者：
Heilbronn, LK;de Jonge, L;Ravussin, E
背景 长期限制热量摄入可延长啮齿类动物的寿命。长期热量限制是否会影响长寿的生物标志物或氧化应激标志物，或降低代谢率是否超出了因减少代谢量而预期的水平，尚未在人体中进行过研究。 目的 研究 6 个月的热量限制（有或没有运动）对超重、非肥胖（体重指数为 25 至 < 30）男性和女性的影响。 设计、设置和参与者 3 月间对健康、久坐的男性和女性 (N = 48) 进行的随机对照试验2002 年和 2004 年 8 月在路易斯安那州巴吞鲁日的一个研究中心进行。 干预 参与者被随机分为 4 组中的一组，为期 6 个月：对照组（维持体重饮食）；热量限制（基准能量需求的 25% 热量限制）；运动中的卡路里限制（12.5% 卡路里限制加上结构化运动导致的能量消耗增加 12.5%）；极低热量饮食（890 kcal/天，直到体重减轻 15%，然后进行体重维持饮食）。 主要结果指标 身体成分；硫酸脱氢表雄酮 (DHEAS)、葡萄糖和胰岛素水平；蛋白质羰基； DNA损伤； 24小时能量消耗；结果 4 组 6 个月时的平均 (SEM) 体重变化如下：对照组，- 1.0% (1.1%)；对照组，- 1.0% (1.1%)；卡路里限制，- 10.4% (0.9%)；运动热量限制，- 10.0% (0.8%)；和极低热量饮食，- 13.9% (0.7%)。 6 个月时，干预组的空腹胰岛素水平较基线显着降低（所有 P
Context Prolonged calorie restriction increases life span in rodents. Whether prolonged calorie restriction affects biomarkers of longevity or markers of oxidative stress, or reduces metabolic rate beyond that expected from reduced metabolic mass, has not been investigated in humans.Objective To examine the effects of 6 months of calorie restriction, with or without exercise, in overweight, nonobese ( body mass index, 25 to < 30) men and women.Design, Setting, and Participants Randomized controlled trial of healthy, sedentary men and women (N=48) conducted between March 2002 and August 2004 at a research center in Baton Rouge, La.Intervention Participants were randomized to 1 of 4 groups for 6 months: control ( weight maintenance diet); calorie restriction (25% calorie restriction of baseline energy requirements); calorie restriction with exercise (12.5% calorie restriction plus 12.5% increase in energy expenditure by structured exercise); very low-calorie diet ( 890 kcal/d until 15% weight reduction, followed by a weight maintenance diet).Main Outcome Measures Body composition; dehydroepiandrosterone sulfate (DHEAS), glucose, and insulin levels; protein carbonyls; DNA damage; 24-hour energy expenditure; and core body temperature.Results Mean (SEM) weight change at 6 months in the 4 groups was as follows: controls, - 1.0% (1.1%); calorie restriction, - 10.4% (0.9%); calorie restriction with exercise, - 10.0% (0.8%); and very low-calorie diet, - 13.9% (0.7%). At 6 months, fasting insulin levels were significantly reduced from baseline in the intervention groups(all P