Vitamin, mineral, and specialty supplements and risk of hematologic malignancies in the prospective VITamins And Lifestyle (VITAL) study.
Vitamin, mineral, and specialty supplements and risk of hematologic malignancies in the prospective VITamins And Lifestyle (VITAL) study.
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DOI：
10.1158/1055-9965.epi-11-0494
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
White E
中科院分区：
文献类型：
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作者：
Walter RB;Brasky TM;Milano F;White E
越来越多的证据表明，水果和蔬菜中的营养素对包括血液恶性肿瘤在内的各种癌症具有化学保护作用，但营养补充剂的作用却没有得到充分的研究。在此，我们前瞻性地评估了维生素、矿物质和特殊补充剂与恶性血液病发生的关系，这些患者来自华盛顿州，年龄在50 - 76岁之间，年龄在2000-2002年期间被纳入VITAL队列研究。通过与监测、流行病学和最终结果（SEER）癌症登记研究的联系，确定了截至2008年12月的血液恶性肿瘤病例（n=588）。使用考克斯比例风险模型估计与补充剂使用相关的风险比（HR）和95%置信区间（95% CI）。调整后，在我们的模型中，大量使用大蒜补充剂（≥4天/周，≥3年; HR=0.55 [95%置信区间：0.34-0.87];趋势p=0.028）和曾经使用葡萄籽补充剂（HR=0.57 [0.37-0.88]）与血液恶性肿瘤呈负相关。此外，多种维生素的高使用率（8-10药丸-年）提示负相关（HR）=0.80 [0.64-1.01]）。相比之下，其余补充剂没有观察到相关性。这些数据表明，大蒜和葡萄籽的使用可能与血液恶性肿瘤的风险降低有关。这是第一个队列研究表明这些补充剂在血液恶性肿瘤的化学预防中可能发挥的作用。
Increasing evidence suggests that nutrients from fruits and vegetables have chemoprotective properties on various cancers including hematologic malignancies, but the effects of nutritional supplements are poorly examined. Herein, we prospectively evaluated the association of vitamin, mineral, and specialty supplements with incident hematologic malignancies in 66,227 men and women aged 50 to 76 years from Washington State recruited from 2000–2002 to the VITamins And Lifestyle (VITAL) cohort study. Hematologic malignancies cases (n=588) were identified through December 2008 by linkage to the Surveillance, Epidemiology, and End Results (SEER) cancer registry. Hazard ratios (HRs) and 95% confidence intervals (95% CI) associated with supplement use were estimated with Cox proportional hazards models. After adjustment, high use of garlic supplements (≥4 days/week for ≥3 years; HR=0.55 [95% confidence interval: 0.34–0.87]; p=0.028 for trend) and ever use of grape seed supplements (HR=0.57 [0.37–0.88]) were inversely associated with hematologic malignancies in our models. In addition, high use (8–10 pill-years) of multivitamins was suggestive of an inverse association (HR)=0.80 [0.64–1.01]). In contrast, no associations were observed for the remaining supplements. These data indicate that use of garlic and grape seed may be associated with reduced risk of hematologic malignancies. This is the first cohort study to suggest a possible role of these supplements in the chemoprevention of hematologic malignancies.