COX 2 selectivity of non-steroidal anti-inflammatory drugs and perioperative blood loss in hip surgery. A randomized comparison of indomethacin and meloxicam
COX 2 selectivity of non-steroidal anti-inflammatory drugs and perioperative blood loss in hip surgery. A randomized comparison of indomethacin and meloxicam
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DOI：
10.1097/00003643-200312000-00005
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发表时间：
2003-12-01
影响因子：
3.6
通讯作者：
Spruit, M
中科院分区：
文献类型：
--
作者：
Weber, EWG;Slappendel, R;Spruit, M
背景资料：在这项前瞻性随机研究中，我们测试的假设，即使用更多的环氧化酶2（考克斯2）选择性非甾体类抗炎药（NSAIDs）可以减少围手术期失血量与非选择性NSAIDs.Methods：数据从200例接受全髋关节置换术进行了研究。比较了两种NSAID：吲哚美辛50 mg（n=82）和美洛昔康15 mg（n=86）。两种非甾体类抗炎药口服1小时前surgic.Results：两组没有不同的年龄，性别，阿萨类或手术时间。术前使用吲哚美辛时，术中失血量为623+/-243 mL（平均值+/-SD），术后失血量为410+/-340 mL。美洛昔康给药后，这些数值分别为524+/-304 mL和358+/-272 mL。美洛昔康组围手术期总失血量为17%（P
Background: In this prospective randomized study we tested the hypothesis that use of more cyclo-oxygenase 2 (COX 2)-selective non-steroidal anti-inflammatory drugs (NSAIDs) can reduce perioperative blood loss compared with non-selective NSAIDs.Methods: Data from 200 patients who underwent total hip replacement were studied. Two NSAIDs were compared: indomethacin 50 mg (n=82) and meloxicam 15 mg (n=86). Both NSAIDs were given orally 1 h before surgery.Results: The two groups were not different with respect to age, gender, ASA class or duration of surgery. When indomethacin was used preoperatively, intraoperative blood loss was 623+/-243 mL (mean+/-SD) and postoperative blood loss 410+/-340 mL. After meloxicam, these values were 524+/-304 mL and 358+/-272 mL, respectively. Total perioperative blood loss after meloxicam was 17% (P