High fever, renal failure, disseminated intravascular coagulation and myelodysplasia accompanied with enhanced angiogenesis possibly due to overexpression of vascular endothelial growth factor.
High fever, renal failure, disseminated intravascular coagulation and myelodysplasia accompanied with enhanced angiogenesis possibly due to overexpression of vascular endothelial growth factor.
复制标题
高热、肾功能衰竭、弥散性血管内凝血和骨髓增生异常，并伴有血管生成增强，可能是由于血管内皮生长因子的过度表达所致。
DOI：
10.2169/internalmedicine.39.570
复制
发表时间：
2000
影响因子：
1.2
通讯作者：
Y. Miura
中科院分区：
文献类型：
--
作者：
H. Murata;H. Yoshimoto;T. Ryu;M. Masuo;J. Toyama;H. Tokuda;S. Kitamura;Y. Miura
一位44岁的女性患有反复发烧，水肿和疲劳。实验室数据显示肾功能不全，低蛋白血症，弥散性血管内凝血（DIC）和骨髓增生异常。肾和淋巴结活检显示明显的血管生成。血清血管内皮生长因子（VEGF）和白细胞介素（IL）-6水平显著升高，提示VEGF诱导的血管生成相关的发病机制。经环孢菌素A治疗后症状缓解。未获得实体瘤、恶性淋巴瘤、Castleman病或POEMS（多发性神经病、器官肿大、内分泌紊乱、M蛋白血症和皮肤变化）综合征（报告可诱导高血清VEGF水平）的证据。这种情况下可能涉及一个未知的机制，诱导VEGF和IL-6的过度表达。
A 44-year-old woman suffered from recurrent fever, edema and fatigue. Laboratory data revealed renal dysfunction, low proteinemia, disseminated intravascular coagulation (DIC) and myelodysplasia. A renal and lymph node biopsy showed a marked angiogenesis. Serum levels of vascular endothelial growth factor (VEGF), and interleukin (IL)-6 were markedly increased, suggesting a pathogenesis related to VEGF-induced angiogenesis. The symptoms were remitted after treatment with cyclosporin A. No evidence of solid tumors, malignant lymphoma, Castleman's disease or POEMS (polyneuropathy, organomegaly, endocrine disorder, M-proteinemia and skin change) syndrome, reported to induce a high serum VEGF level, was obtained. This case may have involved an unknown mechanism which induced an overexpression of VEGF and IL-6.