Deep Venous Thrombosis in COVID-19 Patients: A Cohort Analysis.
Deep Venous Thrombosis in COVID-19 Patients: A Cohort Analysis.
复制标题
COVID-19 患者的深静脉血栓形成：队列分析
DOI：
10.1177/1076029620982669
复制
发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Cai C;Guo Y;You Y;Hu K;Cai F;Xie M;Yang L;Ling K;Ye D;Misra S;Wang W;Li Y
深静脉血栓形成是冠状病毒病2019年(新冠肺炎)的严重并发症。本研究旨在探讨新冠肺炎患者深静脉血栓的患病率、危险因素、抗凝治疗及性别差异。入选的121例住院非呼吸机患者新冠肺炎确诊为阳性。所有疑似患者均接受彩色多普勒超声(US)筛查双腿深静脉血栓。采用多因素Logistic回归分析新冠肺炎患者深静脉血栓形成的危险因素。超声检查发现48%的无症状新冠肺炎患者存在DVT，且Padua指数或Caprini指数升高。多因素Logistic回归分析显示，年龄(OR，1.05；p=.0306)、C反应蛋白(OR，1.02；p=.0040)和基线D-二聚体(OR，1.42；p=.0010)是新冠肺炎患者的危险因素。虽然最常见的深静脉血栓形成部位是踝下(I级和II级)，但证实了深静脉血栓伴新冠肺炎患者的死亡率较高。在整个住院期间，与非DVT-新冠肺炎患者相比，DVT-新冠肺炎患者的C反应蛋白、中性粒细胞计数和D-二聚体显著升高。尽管抗凝治疗加速了DVT患者淋巴细胞减少的恢复，但接受抗凝治疗的男性DVT-新冠肺炎患者的C反应蛋白、中性粒细胞计数与淋巴细胞计数(N/L)比值显著高于女性DVT-新冠肺炎患者，但淋巴细胞计数低于女性DVT-新冠肺炎患者。DVT在具有高危因素的新冠肺炎患者中很常见，尤其是在年龄较大、C反应蛋白和基线D-二聚体水平较高的患者中。在深静脉血栓-新冠肺炎患者的抗凝治疗中考虑性别差异是很重要的。
Deep venous thrombosis (DVT) is a severe complication of coronavirus disease 2019 (COVID-19). The purpose of this study was to study the prevalence, risk factors, anticoagulant therapy and sex differences of DVT in patients with COVID-19. The enrolled 121 hospitalized non-ventilator patients were confirmed positive for COVID-19. All suspected patients received color Doppler ultrasound (US) to screen for DVT in both lower extremities. Multivariate logistic regression was performed to identify risk factors related to DVT in COVID-19 patients. DVT was found in 48% of the asymptomatic COVID-19 patients with an increased PADUA or Caprini index using US scanning. The multivariate logistic regression determined that age (OR, 1.05; p = .0306), C-reactive protein (CRP) (OR, 1.02; p = .0040), and baseline D-dimer (OR, 1.42; p = .0010) were risk factors among COVID-19 patients. Although the most common DVT location was infrapopliteal (classes I and II), higher mortality in DVT-COVID-19 patients was confirmed. DVT-COVID-19 patients presented significant increases in CRP, neutrophil count, and D-dimer throughout the whole inpatient period compared to non-DVT-COVID-19 patients. Although anticoagulation therapy accelerated the recovery of lymphocytopenia in DVT patients, men DVT-COVID-19 patients with anticoagulant therapy showed significant higher CRP and neutrophil count vs. lymphocyte count (N/L) ratio, but showed lower lymphocyte counts compared to women DVT-COVID-19 patients. DVT is common in COVID-19 patients with high-risk factors, especially for older age and higher CRP and baseline D-dimer populations. It is important to consider sex differences in anticoagulant therapy among DVT-COVID-19 patients.
登录
查看更多内容
影响因子：
4.4
作者：
Zhou H;Hu Y;Li X;Wang L;Wang M;Xiao J;Yi Q
通讯作者：
Yi Q
影响因子：
1.7
作者：
Arnoldussen, C. W. K. P.;Wittens, C. H. A.
通讯作者：
Wittens, C. H. A.
影响因子：
9.6
作者：
Kearon, Clive;Akl, Elie A.;Moores, Lisa
通讯作者：
Moores, Lisa
影响因子：
24
作者：
Nadkarni, Girish N.;Lala, Anuradha;Fuster, Valentin
通讯作者：
Fuster, Valentin
影响因子：
37.8
作者：
Parkin, Lianne;Sweetland, Sian;Beral, Valerie
通讯作者：
Beral, Valerie