Arc in synaptic plasticity: from gene to behavior.
Arc in synaptic plasticity: from gene to behavior.
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DOI：
10.1016/j.tins.2011.08.007
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发表时间：
2011-11
影响因子：
15.9
通讯作者：
Finkbeiner S
中科院分区：
文献类型：
--
作者：
Korb E;Finkbeiner S
活性调节细胞骨架(Arc)基因编码一种对巩固记忆至关重要的蛋白质。Arc是已知调控最严格的分子之一：神经元活动控制Arc mRNA的诱导、运输和积累，以及Arc蛋白的产生、定位和稳定性。ARC通过多种机制调节突触强度，参与几乎所有已知形式的突触可塑性。它还参与记忆的形成，并与多种神经系统疾病有关。在这篇综述中，我们将讨论Arc是如何被调节的，并作为研究神经元活动的工具。我们还将试图阐明它的分子功能如何与其对各种形式可塑性的要求相对应，讨论Arc在行为和疾病中的作用，并强调关键的未解决的问题。
The activity-regulated cytoskeletal (Arc) gene encodes a protein that is critical for memory consolidation. Arc is one of the most tightly regulated molecules known: neuronal activity controls Arc mRNA induction, trafficking, and accumulation, and Arc protein production, localization and stability. Arc regulates synaptic strength through multiple mechanisms and is involved in essentially every known form of synaptic plasticity. It also mediates memory formation and is implicated in multiple neurological diseases. In this review, we will discuss how Arc is regulated and used as a tool to study neuronal activity. We will also attempt to clarify how its molecular functions correspond to its requirement for various forms of plasticity, discuss Arc’s role in behavior and disease, and highlight critical unresolved questions.