One-pot synthesis of new 2,4,5-trisubstituted 1,3-thiazoles and 1,3-selenazoles
One-pot synthesis of new 2,4,5-trisubstituted 1,3-thiazoles and 1,3-selenazoles
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DOI：
10.1016/j.tet.2009.01.104
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发表时间：
2009-04-11
期刊：
影响因子：
2.1
通讯作者：
Seck, Pierre
中科院分区：
文献类型：
--
作者：
Thomae, David;Perspicace, Enrico;Seck, Pierre
在本工作中，我们描述了一个简单的一锅四步法合成新的2，4，5-三取代-1，3-噻唑和1，3-硒唑。以氰基二硫代亚氨基碳酸二甲酯为起始原料合成了1，3-噻唑和1，3-硒唑类化合物，收率较高。通过改变胺和活化卤化物的种类，在噻唑和硒唑环上引入了化学多样性。(C)2009爱思唯尔有限公司保留所有权利。
In this work, we describe the synthesis of new 2,4,5-trisubstituted-1,3-thiazoles and 1,3-selenazole achieved by an easy one-pot four-step procedure. Expected compounds were obtained in good yield from dimethyl cyanodithioimidocarbonate, which was the common starting material for the preparation of all 1,3-thiazoles and 1,3-selenazoles, Chemical diversity was introduced on thiazole and selenazole rings by varying the amines and the activated halides used. (C) 2009 Elsevier Ltd. All rights reserved.