Structure and antitumor activity of the less-branched derivatives of an alkali-soluble glucan isolated from Omphalia lapidescens. (Studies on fungal polysaccharide. XXXVIII).
Structure and antitumor activity of the less-branched derivatives of an alkali-soluble glucan isolated from Omphalia lapidescens. (Studies on fungal polysaccharide. XXXVIII).
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DOI：
10.1248/cpb.40.261
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发表时间：
1992-01
影响因子：
1.7
通讯作者：
K. Saito;M. Nishijima;N. Ohno;T. Yadomae;T. Miyazaki
中科院分区：
文献类型：
--
作者：
K. Saito;M. Nishijima;N. Ohno;T. Yadomae;T. Miyazaki
研究了从真菌粗药“雷丸”（雷丸）中分离得到的碱溶性葡聚糖OL-2的史密斯型降解产物（OL-2-I、OL-2-II和OL-2-III）的结构和抗肿瘤活性。甲基化分析表明，OL-2-I是一种（1-3）-β-D-葡聚糖，在每个C-6位置的每三个主链葡糖基单元处约有一个分支; OL-2-II是一种（1-3）-β-D-葡聚糖，在每个C-6位置的二十四个主链葡糖基单元处约有一个分支（所有主链葡糖基单元的数量为平均值）。OL-2的Smith-type降解产物OL-2-I、OL-2-II和OL-2-III对ICR小鼠肉瘤180的实体型具有较强的抗肿瘤活性。这些结果表明，在位置6处的β-连接支化的程度与抗肿瘤活性显著相关。
The structure and antitumor activity of Smith-type degradation products (OL-2-I, OL-2-II and OL-2-III) of an alkali-soluble glucan, OL-2, isolated from a crude fungal drug "Leiwan" (Omphalia lapidescens) were investigated. Methylation analysis suggested that OL-2-I was a (1----3)-beta-D-glucan with approximately one branch at every three main chain glucosyl units at each C-6 position; OL-2-II was a (1----3)-beta-D-glucan with approximately one branch at twenty four main chain glucosyl units at each C-6 position (number of all main chain glucosyl units is on average). OL-2-I, OL-2-II and OL-2-III which were Smith-type degradation products of OL-2, showed potent antitumor activity against the solid form of sarcoma 180 in ICR mice. These results indicated that the degree of beta-linked branching at position 6 was remarkably related to the antitumor activity.