Acceptability of PRO2000 vaginal gel among HIV un-infected women in Pune, India
Acceptability of PRO2000 vaginal gel among HIV un-infected women in Pune, India
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DOI：
10.1080/09540120601133576
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发表时间：
2007-07-01
影响因子：
1.7
通讯作者：
Mehendale, S.
中科院分区：
文献类型：
--
作者：
Joglekar, N.;Joshi, S.;Mehendale, S.
本文报告了PRO2000凝胶（一种候选阴道杀微生物剂）在印度浦那进行的I期安全性研究参与者中的可接受性。42名符合条件的妇女参加了一项研究，要求在月经之间连续14天每天两次使用阴道内产品。在研究退出时，通过在41名完成产品使用的参与者中进行结构化问卷调查，以及涉及31名研究参与者的5个焦点小组讨论，对可接受性进行评估。参与者普遍喜欢该产品（40/41，97.2%），尤其是其颜色（40，97.2%）和稠度（35，85.3%）。34名参与者报告在使用产品后一小时内发生性行为，在研究期间至少发生一次性行为，据报道，性快感在（30，88.2%）参与者中更好或不受影响。近70%的人不喜欢它的气味，并提到喜欢一种男性伴侣不会注意到的产品。参与调查的妇女关注到使用和储存产品的隐私问题。PRO 2000阴道凝胶的可接受性良好，但其气味有待改善。为解决妇女对隐私和储存的关切提供咨询至关重要。妇女对不引人注意的产品的偏好表明她们有能力并愿意接受由女性控制的预防艾滋病毒的选择。
Acceptability of PRO2000 Gel, a candidate vaginal microbicide, among participants of its Phase I safety study in Pune, India is reported here. Forty-two eligible women were enrolled in a study requiring twice daily intra-vaginal product use for 14 consecutive days between menses. Acceptability was assessed at study exit through structured questionnaires among 41 participants who completed the product use, and five focus group discussions involving 31 study participants. The participants generally liked the product (40/41, 97.2%), especially its colour (40, 97.2%) and consistency (35, 85.3%). Thirty-four participants reported sexual intercourse within one hour of product use, at least once during the study period and sexual pleasure was reported to be better or unaffected among (30, 88.2%) participants. Nearly 70% did not like its smell and mentioned preference for a product that would be unnoticeable to the male partner. Participating women were concerned about privacy in usage and storage of the product. Acceptability of PRO2000 vaginal gel was good, but its smell will have to be improved. Counselling to address women's concerns about privacy and storage will be crucial. Women's preference for unnoticeable product indicates their empowerment and willingness to accept female-controlled options for HIV prevention.