Recovery and chronicity in anorexia nervosa: Brain activity associated with differential outcomes
Recovery and chronicity in anorexia nervosa: Brain activity associated with differential outcomes
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DOI：
10.1016/s0006-3223(03)00172-0
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发表时间：
2003-11-01
影响因子：
10.6
通讯作者：
Treasure, J
中科院分区：
文献类型：
--
作者：
Uher, R;Brammer, MJ;Treasure, J
背景：神经性厌食症的病程从快速恢复到慢性衰弱性疾病不等。本研究旨在确定与不同结果相关的功能性神经相关性。方法：通过功能性磁共振成像测量九名从限制神经性厌食症中长期恢复的女性对食物和情绪视觉刺激的大脑反应。将这些研究与年龄和教育程度相匹配的八名患有限制性神经性厌食症的慢性病女性和九名健康对照女性进行比较。 结果：对食物刺激的反应，内侧前额叶和前扣带回激活增加，以及顶下小叶活动缺乏，使康复组与健康对照受试者区分开来。右侧前额叶、顶前额叶和背侧前扣带皮层激活的增加将这些康复者与慢性病患者区分开来。组间差异特定于食物刺激，而情绪刺激的处理在组间没有差异。结论：单独的神经相关因素是神经性厌食症的特征和状态特征的基础。内侧前额叶对疾病特异性刺激的反应可能与特质脆弱性有关。外侧和顶端前额叶受累与良好的结果相关。 (C) 2003 年生物精神病学协会。
Background: The course of anorexia nervosa varies from rapid recovery to a chronic debilitating illness. This study aimed to identify functional neural correlates associated with differential outcomes.Methods: Brain reactions to food and emotional visual stimuli were measured with functional magnetic resonance imaging in nine women who had long-term recovery from restricting anorexia nervosa. These were compared with age- and education-matched groups of eight women chronically ill with restricting anorexia nervosa and nine healthy control women.Results: In response to food stimuli, increased medial prefrontal and anterior cingulate activation, as well as a lack of activity in the inferior parietal lobule, differentiated the recovered group from the healthy control subjects. Increased activation of the right lateral prefrontal, apical prefrontal, and dorsal anterior cingulate cortices differentiated these recovered subjects from chronically ill patients. Group differences were specific to food stimuli, whereas processing of emotional stimuli did not differ between groups.Conclusions: Separate neural correlates underlie trait and state characteristics of anorexia nervosa. The medial prefrontal response to disease-specific stimuli may be related to trait vulnerability. Lateral and apical prefrontal involvement is associated with a good outcome. (C) 2003 Society of Biological Psychiatry.