Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma.
Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma.
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头颈部鳞状细胞癌中的肿瘤微环境与免疫逃逸
DOI：
10.1038/s41368-021-00131-7
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发表时间：
2021-08-02
影响因子：
14.9
通讯作者：
Wang CY
中科院分区：
文献类型：
--
作者：
Elmusrati A;Wang J;Wang CY
头颈部鳞状细胞癌（HNSCC）是一种侵袭性恶性肿瘤，其特点是发病率高、生存率低，除局部手术、传统细胞毒性化疗和放疗外，治疗选择有限。越来越多的研究证实了肿瘤微环境（TME）在癌症进展中的协同作用。尤其是免疫系统，在监测HNSCC的起始、发展和进展过程中发挥着关键作用。了解肿瘤细胞是如何通过自身免疫原性调控或免疫抑制介质的表达来进化并逃避免疫系统，为开发先进疗法奠定了基础。此外，癌细胞与宿主免疫系统之间的相互作用对TME产生有害影响，促进血管生成、增殖和转移。本综述对浸润TME的关键炎症细胞的作用提供了最新见解，重点回顾与HNSCC相关的免疫学原理，如癌症免疫监视和免疫逃逸，还简要概述了当前的免疫治疗策略和正在进行的临床试验。
Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is characterized by high morbidity and low survival rates with limited therapeutic options outside of regional surgery, conventional cytotoxic chemotherapy, and irradiation. Increasing studies have supported the synergistic role of the tumor microenvironment (TME) in cancer advancement. The immune system, in particular, plays a key role in surveillance against the initiation, development, and progression of HNSCC. The understanding of how neoplastic cells evolve and evade the immune system whether through self-immunogenicity manipulation, or expression of immunosuppressive mediators, provides the foundation for the development of advanced therapies. Furthermore, the crosstalk between cancer cells and the host immune system have a detrimental effect on the TME promoting angiogenesis, proliferation, and metastasis. This review provides a recent insight into the role of the key inflammatory cells infiltrating the TME, with a focus on reviewing immunological principles related to HNSCC, as cancer immunosurveillance and immune escape, including a brief overview of current immunotherapeutic strategies and ongoing clinical trials.
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