Life quality assessment among patients with atopic eczema
Life quality assessment among patients with atopic eczema
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DOI：
10.1111/j.1365-2133.2005.07050.x
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发表时间：
2006-04-01
影响因子：
10.3
通讯作者：
Jemec, GBE
中科院分区：
文献类型：
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作者：
Holm, EA;Wulf, HC;Jemec, GBE
研究背景特应性湿疹(AE)患者的生活质量(QOL)与疾病严重程度相关的量化是非常重要的，因为该评估为传统的客观临床评分系统提供了额外的信息。方法采用皮肤病生活质量指数(DLQI)、皮肤病生活质量指数(CDLQI)和皮肤瘙痒程度3种视觉模拟评定量表(VASS)对101例AE患者和30例正常对照进行为期6个月的两次问诊，评估疾病严重程度与生活质量的关系。目的采用症状自评量表(SCORAD)测量疾病严重程度。结果急性脑梗塞患者的生活质量明显低于健康对照组和普通人群。DLQI/CDLQI、瘙痒、患者和研究人员对湿疹严重程度的总体评估显著(P<；0.0001)，并与SCORAD呈正相关，而一般问卷显示相关性较差。SF-36心理部分得分存在性别差异(P=0.019)。结论精神障碍对生活质量有一定影响。患者的心理健康、社交功能和角色情绪功能似乎比身体功能受到的影响更大。患者对疾病严重程度的简单VAS评分与使用的大多数HRQOL方法显示出最高和最显著的相关性。有证据表明，急性脑脊髓炎患者有能力对其疾病严重程度和生活质量做出准确判断。
Background Quantification of quality of life (QoL) related to disease severity is important in patients with atopic eczema (AE), because the assessment provides additional information to the traditional objective clinical scoring systems.Objectives To measure health-related QoL (HRQoL) in patients with AE; to analyse discriminant, divergent and convergent validity by examining the association between various QoL methods; and to examine the association between disease severity assessed by an objective Severity Scoring of Atopic Dermatitis (SCORAD) and QoL.Methods HRQoL was assessed at two visits at a 6-monthly interval in 101 patients with AE and 30 controls with one dermatology-specific questionnaire [Dermatology Life Quality Index (DLQI) or Children's DLQI (CDLQI)], one generic instrument (SF-36) and three visual analogue scales (VASs) of severity and pruritus. Objective SCORAD was used to measure disease severity.Results Patients with AE had significantly lower QoL than healthy controls and the general population. DLQI /CDLQI, pruritus, and patient and investigator overall assessment of eczema severity were significantly (P < 0.0001) and positively correlated with SCORAD, while the generic questionnaire showed only poor correlation. A gender difference was found for the mental component score of SF-36 (P = 0.019).Conclusions AE has an impact on HRQoL. Patients' mental health, social functioning and role emotional functioning seem to be more affected than physical functioning. A simple VAS score of patients' assessment of disease severity showed the highest and most significant correlations with most of the HRQoL methods used. There is evidence to support the ability of patients with AE to make an accurate determination of their disease severity and QoL.