The MOBILIZE Boston Study: design and methods of a prospective cohort study of novel risk factors for falls in an older population.
The MOBILIZE Boston Study: design and methods of a prospective cohort study of novel risk factors for falls in an older population.
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DOI：
10.1186/1471-2318-8-16
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发表时间：
2008-07-18
期刊：
影响因子：
4.1
通讯作者：
Lipsitz LA
中科院分区：
文献类型：
--
作者：
Leveille SG;Kiel DP;Jones RN;Roman A;Hannan MT;Sorond FA;Kang HG;Samelson EJ;Gagnon M;Freeman M;Lipsitz LA
跌倒是美国老年人的第六大死因。尽管人们在理解跌倒的危险因素方面取得了进展，但许多可疑的危险因素尚未得到充分研究。人们对跌倒的可能危险因素，如疼痛、脑血流减少、躯体感觉缺陷和足部疾病知之甚少，部分原因是它们构成了测量方面的挑战，特别是对于大型观察性研究。波士顿动员研究(MBS)是NIA资助的一个项目，是对波士顿地区老年人跌倒的一组独特风险因素进行的前瞻性队列研究。我们采用挨家挨户的人口招聘方式，招募了765名70岁及以上的老年人。基线评估分两个阶段进行：在4周内进行3小时的家庭访谈，然后进行3小时的诊所检查。测量包括疼痛、脑血流动力学和足部疾病，以及确定的跌倒危险因素。对于跌倒的后续行动，参与者在每个月底将秋季日历明信片返还给研究中心。关于跌倒的报道之后，会进行电话采访，以评估每次跌倒的情况和后果。在基线后18个月进行第二次评估。在2382名在门口符合所有资格标准的人中，1616人(67.8%)同意参与，并被转介到研究中心进行进一步筛查。不合格的主要原因是不能用英语交流。前600名参与者的结果显示，参与者在年龄、性别、种族和拉美裔族裔方面基本上代表了波士顿地区的老年人。研究参与者的平均年龄为77.9岁(S.D.5.5)，近三分之二是女性。研究队列中78%是白人，17%是黑人。许多参与者(39%)报告说，在基线之前的一年里至少摔倒过一次。我们的结果证明了在不同的老年人群体中进行全面评估的可行性，包括严格的生理测量，以研究跌倒和残疾的非传统危险因素。MBS将为研究老年人跌倒和行动不便的新风险因素提供重要的新数据来源。
Falls are the sixth leading cause of death in elderly people in the U.S. Despite progress in understanding risk factors for falls, many suspected risk factors have not been adequately studied. Putative risk factors for falls such as pain, reductions in cerebral blood flow, somatosensory deficits, and foot disorders are poorly understood, in part because they pose measurement challenges, particularly for large observational studies. The MOBILIZE Boston Study (MBS), an NIA-funded Program Project, is a prospective cohort study of a unique set of risk factors for falls in seniors in the Boston area. Using a door-to-door population-based recruitment, we have enrolled 765 persons aged 70 and older. The baseline assessment was conducted in 2 segments: a 3-hour home interview followed within 4 weeks by a 3-hour clinic examination. Measures included pain, cerebral hemodynamics, and foot disorders as well as established fall risk factors. For the falls follow-up, participants return fall calendar postcards to the research center at the end of each month. Reports of falls are followed-up with a telephone interview to assess circumstances and consequences of each fall. A second assessment is performed 18 months following baseline. Of the 2382 who met all eligibility criteria at the door, 1616 (67.8%) agreed to participate and were referred to the research center for further screening. The primary reason for ineligibility was inability to communicate in English. Results from the first 600 participants showed that participants are largely representative of seniors in the Boston area in terms of age, sex, race and Hispanic ethnicity. The average age of study participants was 77.9 years (s.d. 5.5) and nearly two-thirds were women. The study cohort was 78% white and 17% black. Many participants (39%) reported having fallen at least once in the year before baseline. Our results demonstrate the feasibility of conducting comprehensive assessments, including rigorous physiologic measurements, in a diverse population of older adults to study non-traditional risk factors for falls and disability. The MBS will provide an important new data resource for examining novel risk factors for falls and mobility problems in the older population.