Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress
Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress
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阿魏酸抑制慢性不可预测的轻度应激小鼠的神经炎症
DOI：
10.1016/j.intimp.2017.02.007
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发表时间：
2017-04-01
影响因子：
5.6
通讯作者：
Yi, Li-Tao
中科院分区：
文献类型：
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作者：
Liu, Ya-Min;Shen, Ji-Duo;Yi, Li-Tao
阿魏酸是广泛存在于植物细胞壁组分中的羟基肉桂酸。在强迫游泳实验和悬尾实验中，阿魏酸添加剂均能减轻小鼠的抑郁样行为。鉴于抑郁症是一种炎症相关的精神疾病，本研究旨在探讨阿魏酸对慢性不可预知轻度应激（CHMS）小鼠小胶质细胞活化、促炎细胞因子、核因子-κ B（NF-κ B）和核甘酸结合和寡聚化结构域样受体家族蛋白激酶3（NLRP 3）炎性小体的调节作用。我们的研究结果首次表明，阿魏酸和氟西汀给药四周后，蔗糖偏好性下降和不动时间增加被完全逆转。然后，我们发现，在前额叶皮层中，BRAS显著引起白细胞介素-1 β（IL-1（3））、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）上调、小胶质细胞、NF-κ B信号传导和NLRP 3炎性体激活。阿魏酸和氟西汀均能逆转BRAS诱导的炎症反应，提示阿魏酸的抗抑郁作用可能与抗炎机制有关。(C)2017年爱思唯尔通过。All rights reserved.
Ferulic acid is a hydroxycinnamic acid that widely presents in plant tell wall components. It has been demonstrated that ferulic add can attenuate depressive-like behaviors in both forced swimming test and tail suspension test. Considering that depression is an inflammatory related mental disease, our present study was aimed to investigate the role of ferulic add in the regulation of microglia activation, pro-inflammatory cytokines, nuclear factor kappa B (NF-kappa B) and nucleotide binding and oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome in mice exposed to chronic unpredictable mild stress (CUMS). Our results firstly showed that decreased sucrose preference and increased immobility time were completely reversed by administration with ferulic acid and fluoxetine for four weeks. Then, we found that CUMS significantly caused interleukin-1 beta (IL-1(3), interleukin-6 (IL-6) and tumor necrosis factor -alpha (TNF-alpha) up-regulation, microglia, NF-kappa B signaling and NLRP3 inflammasome activation in the prefrontal cortex. On the contrary, these activated inflammatory response induced by CUMS were reversed by ferulic add and fluoxetine as well, suggesting that anti-inflammatory related mechanism was involved in the antidepressant-like effects of ferulic acid in stressed mice. (C) 2017 Elsevier By. All rights reserved.