FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells
FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells
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FoxO 调节人内皮细胞中黄体酮诱导的蜕膜蛋白 (DEPP) 的表达
DOI：
10.1016/j.febslet.2011.04.024
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发表时间：
2011-06-23
期刊：
影响因子：
3.5
通讯作者：
Li, Hao
中科院分区：
文献类型：
--
作者：
Chen, Simin;Gai, Junfang;Li, Hao
DEPP最初是从人子宫内膜间质细胞cDNA文库中克隆的，但DEPP的转录调控机制仍不清楚。我们在这里证明了DEPP在人内皮细胞中的表达是FoxO依赖性的。在DEPP启动子中鉴定了两个功能性FoxO响应元件。缺氧刺激内皮细胞系EA表达DEPP。hy926.缺氧诱导的DEPP上调依赖于FoxO表达。我们的结论是DEPP在转录水平的调节FoxO在人血管内皮细胞。(C)2011年欧洲生物化学学会联合会。Elsevier B.V.出版，保留所有权利。
DEPP was initially cloned from the human endometrial stromal cell cDNA library, but the transcriptional regulation of DEPP remains largely unknown. We demonstrate here that expression of DEPP is FoxO-dependent in human endothelial cells. Two functional FoxO-responsive elements are identified in the DEPP promoter. Hypoxia stimulates DEPP expression in the endothelial cell line EA. hy926. Hypoxia-induced upregulation of DEPP is dependent on FoxO expression. We conclude that DEPP is regulated at the level of transcription by FoxO in human vascular endothelial cells. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.