Endocrine basis for weight gain after fasting or VMH lesion in rats.
Endocrine basis for weight gain after fasting or VMH lesion in rats.
复制标题
大鼠禁食或 VMH 损伤后体重增加的内分泌基础。
DOI：
10.1152/ajpendo.1983.245.3.e246
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
J. Le Magnen
中科院分区：
文献类型：
--
作者：
L. Pénicaud;C. Larue‐Achagiotis;J. Le Magnen
为了研究一些激素和代谢因素对体脂量、食物摄入和昼夜脂肪生成-脂肪分解模式的调节，在被认为低于其体脂肪质量调节水平的两组大鼠[在“动态”中具有腹内侧下丘脑核（VMH）损伤的大鼠，肥胖和食物限制大鼠在再喂养阶段的反应]与其他两组在该水平的反应（VMH损伤大鼠在“静态”阶段和正常大鼠）进行比较。葡萄糖耐量和胰岛素释放在动态阶段和在较小程度上在再喂养期间比在静态阶段和正常喂养。在正常大鼠中发现的昼夜差异在动态和喂食动物中消失，并在静止相水平上重新出现。因此，在低于其体脂量调节水平的大鼠中，负责夜间脂肪生成增加和相对摄食量增加以及白天脂肪分解伴摄食量减少的正常昼夜激素代谢模式丢失，并在动物中恢复到该水平。
To study some hormonal and metabolic factors contributing to the regulation of body fat mass, food intake, and the circadian lipogenesis-lipolysis pattern, insulin and glucose responses to intravenous glucose loads were measured in both phases of the light-dark cycle in two groups of rats considered to be below their level of body fat mass regulation [rats with lesion of the ventromedial hypothalamus nuclei (VMH) in the "dynamic" phase of obesity and food-restricted rats during the refeeding phase] compared with the responses of two other groups at this level (VMH-lesioned rats in "static" phase and normal rats). Glucose tolerance and insulin release were greater during the dynamic phase and to a lesser degree during refeeding than during the static phase and normal feeding. The differences between night and day found in normal rats disappeared in dynamic and refed animals and reappeared at the level of static phase. Thus the normal circadian hormonal metabolic patterns responsible for increased lipogenesis and relative hyperphagia during the night and lipolysis with hypophagia during the day were lost in rats below their level of body fat mass regulation and were reinstated in animals on returning to this level.