Dispositional optimism predicts survival status 1 year after diagnosis in head and neck cancer patients
Dispositional optimism predicts survival status 1 year after diagnosis in head and neck cancer patients
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DOI：
10.1200/jco.2003.10.092
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发表时间：
2003-02-01
影响因子：
45.3
通讯作者：
Gilain, L
中科院分区：
文献类型：
--
作者：
Allison, PJ;Guichard, C;Gilain, L
目的;:本研究的目的是调查这样一个假设，即与其他已知的预后因素无关，悲观的头颈部（H & N）癌症患者在诊断后一年内死亡的风险比乐观的患者更大。采用前瞻性观察研究设计，对1997年3月1日至8月31日期间诊断的H & N癌症患者进行队列研究，1998年，法国克莱蒙-费兰德大学中心医院。性格乐观（DO）进行了评估，在基线使用法语版本的生活取向测试翻译和验证本研究。收集所有受试者的1年生存状态。DO和I-年生存率之间的假设关联进行了分析，使用多元Logistic回归分析，控制其他社会人口统计学和临床variables. Results：样本量为101例患者，代表所有，但其中一个患者符合纳入标准谁被诊断在招募期间。其中，51例在诊断后1年仍存活，45例死亡，5例失访。对96例已知1年生存状态的受试者的数据进行多因素分析。控制已知的H & N癌症生存预测因素，悲观的受试者（比值比[OR]，1.12; 95%置信区间[CI]，1.01至1.24）和独居者（OR，4.14; 95%CI，1.21~14.17）比乐观者和与他人同居者1年死亡的可能性大。这项对法国H & N癌症患者队列的研究结果表明，性格乐观预测1年生存率，与其他社会人口统计学和临床变量无关。(C)2003年，美国临床肿瘤学会。
Purpose; : The aim of this study was to investigate the hypothesis that, independent of other known prognostic factors, pessimistic head and neck (H&N) cancer patients have a greater risk of being dead I year after diagnosis than do optimistic patients.Patients and Methods: A prospective observational study design was used with a cohort of H&N cancer patients diagnosed during the period from March 1, 1997, to August 31, 1998, at the Centre Hospitalier Universitaire, Clermont-Ferrand, France. Dispositional optimism (DO) was evaluated at baseline using a French version of the Life Orientation Test translated and validated for this study. One-year survival status was collected on all subjects. The analysis of the hypothesized association between DO and I-year survival was performed using multiple logistic regression analysis, controlling for other sociodemographic and clinical variables.Results: The sample size was 101 patients, representing all but one of those patients fitting the inclusion criteria who were diagnosed during the recruitment period. Of these, 51 were alive at I year after diagnosis, 45 were dead, and five were lost to follow-up. The multivariate analysis was performed on the data from the 96 subjects in whom 1-year survival status was known. Controlling for known predictors of H&N cancer survival, pessimistic subjects (odds ratio [OR], 1.12; 95% confidence interval [CI], 1.01 to 1.24) and those living alone (OR, 4.14; 95% Cl, 1.21 to 14.17) were more likely than optimistic subjects and those living with others to be dead at I year.Conclusion: The results of this study of a cohort of French H&N cancer patients indicate that dispositional optimism predicts 1-year survival independent of other sociodemographic and clinical variables. (C) 2003 by American Society of Clinical Oncology.