Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct.
Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct.
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母系印记基因Qpct的鉴定及表观遗传学分析
DOI：
10.14348/molcells.2015.0098
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发表时间：
2015-10
影响因子：
3.8
通讯作者：
Wu Q
中科院分区：
文献类型：
--
作者：
Guo J;He H;Liu Q;Zhang F;Lv J;Zeng T;Gu N;Wu Q
大多数印记基因与胚胎发育，特别是胎盘发育有关。在这里，我们确定了胎盘特异性印迹基因Qpct。我们的研究结果表明，Qpct广泛表达在早期胚胎发育，并可以检测到在端头，中脑，菱脑在E9.5-E11.5。此外，Qpct在E15.5的大脑、肺和肝脏中显着表达。在胎盘发育过程中，Qpct的表达信号在E15.5达到峰值，并且仅在E15.5胎盘的迷路层中检测到。ChIP分析结果表明，组蛋白H3 K4 me 3的修饰可导致Qpct的母体激活。
Most imprinted genes are concerned with embryonic development, especially placental development. Here, we identified a placenta-specific imprinted gene Qpct. Our results show that Qpct is widely expressed during early embryonic development and can be detected in the telecephalon, midbrain, and rhombencephalon at E9.5–E11.5. Moreover, Qpct is strikingly expressed in the brain, lung and liver in E15.5. Expression signals for Qpct achieved a peak at E15.5 during placental development and were only detected in the labyrinth layer in E15.5 placenta. ChIP assay results suggest that the modification of histone H3K4me3 can result in maternal activating of Qpct.