Antidiabetic Effect of an Active Fraction Extracted from Dragon's Blood (Dracaena Cochinchinensis)
Antidiabetic Effect of an Active Fraction Extracted from Dragon's Blood (Dracaena Cochinchinensis)
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DOI：
10.1080/14756360801936399
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发表时间：
2009-01-01
影响因子：
5.6
通讯作者：
Zhang, Xia-Bing
中科院分区：
文献类型：
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作者：
Gu, Hui-Juan;Lv, Jing-Ci;Zhang, Xia-Bing
龙血提取物活性部位对α-葡萄糖苷酶活性有抑制作用，IC50为0.152g/mL，接近粗品的一半。其对α-葡萄糖苷酶的抑制是非竞争性的。此外，当该级分口服给予给予阿卡波糖（20mg/kg）的小鼠时，活性级分（100、300、500mg/kg）以剂量依赖性方式显着抑制蔗糖负荷后血糖水平的升高。这些结果表明，这种龙血提取物通过抑制肠道碳水化合物吸收从而减少餐后血糖升高而发挥抗糖尿病作用。
The active fraction extracted from dragon's blood displayed an inhibitory effect on alpha-glucosidase activity with an IC50 of 0.152g/mL, which is nearly half of the crude material. Its inhibition on alpha-glucosidase was noncompetitive. In addition, when this fraction was orally administered to mice dosed with Acarbose (20mg/kg), the active fraction (100, 300, 500mg/kg) significantly suppressed increase of blood glucose levels after sucrose loading in a dose-dependent manner. These results suggest that this extract from dragon's blood exerts an anti-diabetic effect by suppressing intestinal carbohydrate absorption and thereby reducing the postprandial increase of blood glucose.