Possible role of contact following in the generation of coherent motion of Dictyostelium cells
Possible role of contact following in the generation of coherent motion of Dictyostelium cells
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DOI：
10.1006/jtbi.2002.3124
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发表时间：
2002-12-07
影响因子：
2
通讯作者：
Inouye, K
中科院分区：
文献类型：
--
作者：
Umeda, T;Inouye, K
通过趋化作用聚集后，细胞黏液霉盘藻的细胞形成多细胞结构，并表现出涡流等连贯运动。在这里，我们提出了一个数学模型来解释细胞在二维空间中的聚集和相干运动。该模型结合了细胞的趋化反应和细胞的特性，称为“接触跟随”，以跟随与它们接触的其他细胞。利用该模型进行的分析研究和计算机模拟表明，随着接触的跟随，细胞形成圆形簇，细胞在其中发生旋转。细胞在长条带中的单向运动是该模型的另一种解。此外，接触跟踪对细胞簇的融合有促进作用。通过考虑细胞运动的机制，提出了接触跟随的可能解释。(C)2002爱思唯尔科学有限公司。保留所有权利。
After aggregation by chemotaxis, cells of the cellular slime mold Dietyostelium discoideum form a multicellular structure and show coherent motion such as vortices. Here, we present a mathematical model to explain both aggregation and coherent motion of cells in two-dimensional space. The model incorporates chemotactic response of cells and the cell's property, called "contact following", to follow the other cells with which they are in contact. Analytical study and computer simulation using the model show that with contact following, cells form circular clusters within which cell rotation occurs. Unidirectional cell motion in a long belt of cells is another type of solution of the model. Besides, contact following has an effect to accelerate cell cluster merging. By considering the mechanism of cell movement, possible explanations of contact following are proposed. (C) 2002 Elsevier Science Ltd. All rights reserved.