Field effectiveness of vaccination against tick-borne encephalitis
Field effectiveness of vaccination against tick-borne encephalitis
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DOI：
10.1016/j.vaccine.2007.08.024
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发表时间：
2007-10-23
期刊：
影响因子：
5.5
通讯作者：
Kundi, Michael
中科院分区：
文献类型：
--
作者：
Heinz, Franz X.;Holzmann, Heidemarie;Kundi, Michael
蜱传脑炎（TBE）是一种疫苗可预防的疾病，由黄病毒（TBE病毒）引起，在许多欧洲国家和中亚和东亚大部分地区流行。在欧洲，高度纯化的正规灭活全病毒疫苗被广泛使用，但疫苗接种覆盖率在有流行性脑炎流行的国家之间差别很大。奥地利呈现出一种特殊的情况，因为88%的总人口有破伤风疫苗接种史，58%的人在推荐的时间表内定期接种疫苗。在这项研究中，我们调查了2000-2006年奥地利不同年龄组流行性腮腺炎疫苗接种的现场有效性，依据是未接种疫苗和接种疫苗的人群住院病例的记录数量，以及代表性调查显示的这些人群的规模。我们表明，定期接种疫苗的人的总体有效性约为99%，年龄组之间没有统计学上的显著差异。在前两次接种疫苗之后，即在第三次接种完成基本疫苗接种计划之前，这一比例至少同样高，但在有不定期疫苗接种记录的人中，这一比例明显较低（约95%）。我们的数据证实了TBE疫苗在野外条件下的优异表现，并提供证据表明，在奥地利，2000-2006年通过接种疫苗预防了约2800例病例。(D 2007爱思唯尔有限公司版权所有。
Tick-borne encephalitis (TBE) is a vaccine-preventable disease caused by a flavivirus (TBE virus) that is endemic in many European countries and large parts of Central and Eastern Asia. In Europe, highly purified formal in -inactivated whole virus vaccines are in widespread use, but the vaccination coverage differs significantly between countries with TBE endemicity. Austria presents an exceptional situation because 88% of the total population have a history of TBE vaccination, with 58% being regularly vaccinated within the recommended schedule. In this study, we investigated the field effectiveness of TBE vaccination in Austria for the years 2000-2006 in different age groups on the basis of the documented numbers of hospitalized cases in unvaccinated and vaccinated people and the sizes of these population groups as revealed by representative inquiries. We show that the overall effectiveness in regularly vaccinated persons is about 99% with no statistically significant difference between age groups. It is at least as high after the first two vaccinations, i.e. before the completion of the basic vaccination scheme by a third vaccination, but is significantly lower (about 95%) in those with a record of irregular vaccination. Our data confirm the excellent performance of TBE vaccine under field conditions and provide evidence that, in Austria, about 2800 cases were prevented by vaccination in the years 2000-2006. (D 2007 Elsevier Ltd. All rights reserved.