Higher serum prolyl endopeptidase activity in patients with post-traumatic stress disorder.
Higher serum prolyl endopeptidase activity in patients with post-traumatic stress disorder.
复制标题
创伤后应激障碍患者血清脯氨酰内肽酶活性较高。
DOI：
10.1016/s0165-0327(98)00086-x
复制
发表时间：
1999
影响因子：
6.6
通讯作者：
S. Scharpe
中科院分区：
文献类型：
--
作者：
M. Maes;A. Lin;S. Bonaccorso;F. Goossens;A. Gastel;R. Pioli;Laure Delmeire;S. Scharpe
背景据报道，精神疾病，如抑郁症和精神分裂症，与脯氨酰内肽酶（EC 3.4.21.26），一种细胞溶质内肽酶，目的和方法本研究的目的是检测创伤后应激障碍（PTSD）患者血清PEP活性，与健康志愿者进行对比。PEP活性已被确定由荧光assay.ResultsSerum PEP活性显着高于PTSD患者比正常志愿者。PTSD合并抑郁症患者血清PEP活性显著高于PTSD不合并抑郁症患者。在PTSD患者中，血清PEP活性与PTSD症状的严重程度之间无显著相关性。结论结果表明，PTSD，特别是PTSD并发抑郁症与PEP活性增加有关。相关性这些结果可能对（i）PTSD的神经内分泌病理生理学具有重要意义，因为PEP降解神经肽，如精氨酸加压素（AVP）和促甲状腺激素释放激素（TRH）;和（ii）PTSD的病因学，因为PEP降解行为活性神经肽，如AVP、TRH、催产素、神经降压素和P物质，其在正强化、社会互动、情绪和应激反应中起关键作用。
BackgroundIt is reported that psychiatric disorders, such as depression and schizophrenia, are associated with changes in serum activity of prolyl endopeptidase (EC 3.4.21.26), a cytosolic endopeptidase, which cleaves peptide bonds on the carboxylside of proline in proteins of relatively small molecular mass.Aims and methodsThe aims of the present study were to examine serum PEP activity in patients with post-traumatic stress disorder (PTSD) versus healthy volunteers. PEP activity has been determined by a fluorimetric assay.ResultsSerum PEP activity was significantly higher in patients with PTSD than in normal volunteers. Serum PEP activity was significantly higher in patients with PTSD and concurrent major depression than in patients with PTSD without major depression. In PTSD patients, there were no significant correlations between serum PEP activity and severity of PTSD symptoms.ConclusionsThe results show that PTSD and, in particular, PTSD with concurrent major depression is associated with increased activity of PEP.Relevancethese results may be of importance for the (i) neuroendocrine pathophysiology of PTSD since PEP degrades neuropeptides, such as arginine vasopressin (AVP) and thyrotropin releasing hormone (TRH); and (ii) etiology of PTSD, since PEP degrades behaviorally active neuropeptides, such as AVP, TRH, oxytocin, neurotensin and substance P, which play a key role in positive reinforcement, social interactions, emotions and stress responsivity.