Rodent models of alcoholic liver disease: of mice and men.
Rodent models of alcoholic liver disease: of mice and men.
复制标题
DOI：
10.1016/j.alcohol.2012.08.004
复制
发表时间：
2012-12
期刊：
影响因子：
2.3
通讯作者：
McKillop, Iain H.
中科院分区：
文献类型：
--
作者：
Brandon-Warner, Elizabeth;Schrum, Laura W.;Schmidt, C. Max;McKillop, Iain H.
关键词：
酒精性肝病（ALD）是全球急性和慢性肝病的主要原因。ALD的进展性质得到了很好的描述，但是这些病理演变的复杂相互作用仍有待充分阐明。临床上，ALD没有明确的生物标志物或普遍接受的有效治疗策略。ALD的实验模型是确定酒精诱导损伤的潜在机制的重要组成部分，以开发更好的诊断标志物，疾病进展的预测因子和治疗靶点，以管理，停止或逆转疾病进展。啮齿动物仍然是研究ALD病理学最容易获得的模型。有效的啮齿动物模型必须模拟ALD的自然病程，同时允许检查多种肝脏和非肝脏细胞类型在改变的代谢或氧化/亚硝化应激、炎症反应和对细胞毒性应激的敏感性的情况下的复杂相互作用。此外，酒精输送的模式和持续时间影响肝脏反应，并在理解疾病病理学方面提出了独特的挑战。本文综述了ALD的啮齿动物模型，其相对于人类疾病状态的优势和劣势，并提供了开发新型啮齿动物模型来模拟人类ALD过程的潜力。
Alcoholic liver disease (ALD) is a major cause of acute and chronic liver disease worldwide. The progressive nature of ALD is well described however the complex interactions under which these pathologies evolve remain to be fully elucidated. Clinically there are no clear biomarkers or universally accepted, effective treatment strategies for ALD. Experimental models of ALD are an important component in identifying underlying mechanisms of alcohol-induced injury to develop better diagnostic markers, predictors of disease progression, and therapeutic targets to manage, halt, or reverse disease progression. Rodents remain the most accessible model for studying ALD pathology. Effective rodent models must mimic the natural history of ALD while allowing examination of complex interactions between multiple hepatic, and non-hepatic, cell types in the setting of altered metabolic or oxidative/nitrosative stress, inflammatory responses, and sensitivity to cytotoxic stress. Additionally, mode and duration of alcohol delivery influences hepatic response and presents unique challenges in understanding disease pathology. This review provides an overview of rodent models of ALD, their strengths and weaknesses relative to human disease states, and provides insight of the potential to develop novel rodent models to simulate the course of human ALD.
登录
查看更多内容
影响因子：
25.7
作者：
Butura, Angelica;Nilsson, Kerstin;Ingelman-Sundberg, Magnus
通讯作者：
Ingelman-Sundberg, Magnus
DOI：
10.1073/pnas.1101791108
发表时间：
2011-07-19
影响因子：
11.1
作者：
Chen, Alice A.;Thomas, David K.;Bhatia, Sangeeta N.
通讯作者：
Bhatia, Sangeeta N.
DOI：
10.1128/cdli.12.1.60-67.2005
发表时间：
2005-01-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
Copeland, S;Warren, HS;Remick, D
通讯作者：
Remick, D
影响因子：
--
作者：
Beier JI;Arteel GE;McClain CJ
通讯作者：
McClain CJ
影响因子：
2
作者：
DeNucci, Sarah M.;Tong, Ming;de la Monte, Suzanne M.
通讯作者：
de la Monte, Suzanne M.