Regional cerebral blood flow in mood disorders, V.: Effects of antidepressant medication in late-life depression.
Regional cerebral blood flow in mood disorders, V.: Effects of antidepressant medication in late-life depression.
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DOI：
10.1097/00019442-200011000-00004
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发表时间：
2000-09
期刊：
影响因子：
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通讯作者：
M. Nobler;S. Roose;I. Prohovnik;J. Moeller;J. Louie;R. V. Van Heertum;H. Sackeim
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文献类型：
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作者：
M. Nobler;S. Roose;I. Prohovnik;J. Moeller;J. Louie;R. V. Van Heertum;H. Sackeim
对20例老年重度抑郁症门诊患者分别给予去甲替林或舍曲林治疗。静息区域脑血流量（rCBF）在药物洗脱和抗抑郁治疗6- 9周后通过平面（133）氙气吸入技术进行评估。在基线时，与20名匹配的正常对照受试者相比，抑郁样本额叶皮质区域的rCBF减少。治疗后，响应者和无响应者在特定地形改变的表达上存在差异，响应者表现为额叶区域灌注减少。这些发现与该小组之前关于电休克治疗（ECT）反应后rCBF减少的报告一致，并提示了一种共同的作用机制。
Twenty elderly outpatients with major depression were treated with either nortriptyline or sertraline. Resting regional cerebral blood flow (rCBF) was assessed by the planar (133)Xenon inhalation technique after a medication washout and following 6- 9 weeks of antidepressant treatment. At baseline, the depressed sample had reduced rCBF in frontal cortical regions when compared with 20 matched normal-control subjects. After treatment, Responders and Nonresponders differed in the expression of a specific topographic alteration, with Responders manifesting reduced perfusion in frontal regions. These findings are consistent with this group's previous report of reduced rCBF after response to electroconvulsive therapy (ECT) and suggest a common mechanism of action.