Nanoliposomes: Preparation and Analysis
Nanoliposomes: Preparation and Analysis
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DOI：
10.1007/978-1-60327-360-2_2
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发表时间：
2010-01-01
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影响因子：
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通讯作者：
Mozafari, M. R.
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文献类型：
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作者：
Mozafari, M. R.
纳米脂质体是近年来发展起来的一种新型生物活性物质的包封和释放技术。可以掺入纳米脂质体的生物活性材料的列表是巨大的，从药物到化妆品和营养品。由于其生物相容性和生物降解性，沿着其纳米尺寸，纳米脂质体在广泛的领域中具有潜在的应用，包括纳米治疗（例如诊断、癌症治疗、基因递送）、化妆品、食品技术和农业。纳米脂质体能够通过改善其溶解度和生物利用度、体外和体内稳定性以及防止其与其他分子的不必要的相互作用来增强生物活性剂的性能。纳米脂质体的另一个优势是细胞特异性靶向，这是获得靶点最佳治疗功效所需药物浓度同时最大限度地减少对健康细胞和组织的不良影响的先决条件。本章涵盖了纳米脂质体，特别是关于其性质，制备方法和分析。
Nanoliposome, or submicron bilayer lipid vesicle, is a new technology for the encapsulation and delivery of bioactive agents. The list of bioactive material that can be incorporated to nanoliposomes is immense, ranging from pharmaceuticals to cosmetics and nutraceuticals. Because of their biocompatibility and biodegradability, along with their nanosize, nanoliposomes have potential applications in a vast range of fields, including nanotherapy (e.g. diagnosis, cancer therapy, gene delivery), cosmetics, food technology and agriculture. Nanoliposomes arc able to enhance the performance of bioactive agents by improving their solubility and bioavailability, in vitro and in vivo stability, as well as preventing their unwanted interactions with other molecules. Another advantage of nanoliposomes is cell-specific targeting, which is a prerequisite to attain drug concentrations required for optimum therapeutic efficacy in the target site while minimising adverse effects on healthy cells and tissues. This chapter covers nanoliposomes, particularly with respect to their properties, preparation methods and analysis.