Experimental colitis in rats induces low-grade endotoxinemia without hepatobiliary abnormalities
Experimental colitis in rats induces low-grade endotoxinemia without hepatobiliary abnormalities
复制标题
大鼠实验性结肠炎诱发低度内毒素血症，但无肝胆异常
DOI：
10.1007/bf02093785
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发表时间：
2005
影响因子：
3.1
通讯作者：
PhD R. A. F. M. Chamuleau MD
中科院分区：
文献类型：
--
作者：
M. M. H. S. Brand PhD;PhD A. Bosma MD;PhD R. J. Van Ketel MD;PhD P. Speelman MD;PhD R. A. F. M. Chamuleau MD
在三种大鼠实验模型中，手术构建自填充盲袢（SFBL）、三硝基苯磺酸（TNB）诱导的结肠炎以及SFBL和TNB联合使用，研究了精氨酸衍生内毒素在慢性炎症性肠病（CIBD）肝胆疾病发病机制中发挥作用的假设。治疗8周后，在SFBL + TNB大鼠中观察到门静脉和全身内毒素水平和白细胞介素-6浓度轻度增加，血清碱性磷酸酶、胆红素和ALAT水平仅轻度增加。肝脏的组织学检查在所有三种大鼠模型中几乎没有显示任何异常。这些结果表明，由细菌过度生长和/或化学性结肠炎诱导的大鼠低度门静脉和全身内毒素血症不能诱导肝胆改变。然而，为了明确排除门脉内毒素血症在CIBD相关肝胆异常发病机制中的可能作用，迫切需要一种适当的CIBD动物模型。
In three experimental models in rats, surgical construction of a self-filling blind loop (SFBL), trinitrobenzene sulfonic acid (TNB) -induced colitis, and the combination of SFBL and TNB, the hypothesis was studied that intestine-derived endotoxins play a role in the pathogenesis of hepatobiliary disorders in chronic inflammatory bowel disease (CIBD). After eight weeks of treatment, a mild increase in portal and systemic endotoxin levels and interleukin-6 concentrations was observed and the serum levels of alkaline phosphatase, bilirubin, and ALAT were only mildly increased in SFBL plus TNB rats. Histopathological examination of the liver showed hardly any abnormalities in all three rat models. These results show that low-grade portal and systemic endotoxinemia in rats, induced by bacterial overgrowth and/or chemical colitis, is not able to induce hepatobiliary alterations. To exclude definitively a possible role for portal endotoxinemia in the pathogenesis of CIBD-associated hepatobiliary abnormalities, however, an adequate animal model for CIBD is urgently needed.
影响因子：
29.4
作者：
YAMADA, T;MARSHALL, S;GRISHAM, MB
通讯作者：
GRISHAM, MB
影响因子：
29.4
作者：
LICHTMAN, SN;KEKU, J;SARTOR, RB
通讯作者：
SARTOR, RB
影响因子：
29.4
作者：
LICHTMAN, SN;SARTOR, RB;SCHWAB, JH
通讯作者：
SCHWAB, JH