Type-1 Hepatorenal Syndrome Associated With Infections in Cirrhosis: Natural History, Outcome of Kidney Function, and Survival
Type-1 Hepatorenal Syndrome Associated With Infections in Cirrhosis: Natural History, Outcome of Kidney Function, and Survival
复制标题
DOI：
10.1002/hep.26687
复制
发表时间：
2014-04-01
期刊：
影响因子：
13.5
通讯作者：
Gines, Pere
中科院分区：
文献类型：
--
作者：
Barreto, Rogelio;Fagundes, Claudia;Gines, Pere
Type-1 hepatorenal syndrome (HRS) is a common complication of bacterial infections in cirrhosis, but its natural history remains undefined. To assess the outcome of kidney function and survival of patients with type-1 HRS associated with infections, 70 patients diagnosed during a 6-year period were evaluated prospectively. Main outcomes were no reversibility of type-1 HRS during treatment of the infection and 3-month survival. Forty-seven (67%) of the 70 patients had no reversibility of type-1 HRS during treatment of the infection. [Correction to previous sentence added March 10, 2014, after first online publication: "Twenty-three (33%)" was changed to "Forty-;seven (67%)."] The main predictive factor of no reversibility of type-1 HRS was absence of infection resolution (no reversibility: 96% versus 48% in patients without and with resolution of the infection; P < 0.001). Independent predictive factors of no reversibility of type-1 HRS were age, high baseline serum bilirubin, nosocomial infection, and reduction in serum creatinine
