Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica
Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica
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DOI：
10.1007/s00439-002-0899-8
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发表时间：
2003-05-01
期刊：
影响因子：
5.3
通讯作者：
Ruiz-Linares, A
中科院分区：
文献类型：
--
作者：
Carvajal-Carmona, LG;Ophoff, R;Ruiz-Linares, A
我们报告了具有平行人口统计历史的两个群体分离株的比较遗传特征：哥斯达黎加的中央谷（CVCR）和安蒂奥基亚（位于哥伦比亚西北部）。线粒体DNA、Y染色体和常染色体多态性分析表明，安蒂奥基亚和CVCR在遗传上非常相似，表明这两个分离株的亲本群体关系密切。在这两个群体中，男性祖先主要是欧洲人，而女性祖先主要是美洲人。在协议与他们的隔离，美洲印第安人的mtDNA多样性的安蒂奥基亚和CVCR是典型的种族定义的本地人口，是显着低于其他拉丁美洲人口。比较安蒂奥基亚和CVCR的18个标记对的连锁不平衡（LD），发现两个群体中LD的标记都位于较短的遗传距离（
We report a comparative genetic characterization of two population isolates with parallel demographic histories: the Central Valley of Costa Rica (CVCR) and Antioquia (in northwest Colombia). The analysis of mtDNA, Y-chromosome and autosomal polymorphisms shows that Antioquia and the CVCR are genetically very similar, indicating that closely related parental populations founded these two isolates. In both populations, the male ancestry is predominantly European, whereas the female ancestry is mostly Amerind. In agreement with their isolation, the Amerindian mtDNA diversity of Antioquia and the CVCR is typical of ethnically-defined native populations and is markedly lower than in other Latin American populations. A comparison of linkage disequilibrium (LD) at 18 marker pairs in Antioquia and the CVCR shows that markers in LD in both populations are located at short genetic distances (