The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults
The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults
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DOI：
10.1210/jc.85.3.1170
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发表时间：
2000-03-01
影响因子：
5.8
通讯作者：
Tuttle, RM
中科院分区：
文献类型：
--
作者：
Fenton, CL;Lukes, Y;Tuttle, RM
Ret/PTC重排(PTC-1、PTC-3和PTC-3)是乳头状甲状腺癌(PTC)的特征。在成年人中，PTC-1很常见，可能与侵袭性的临床病程有关。在儿童中，ret/PTC突变的发生率和意义尚不清楚。我们检查了33名患者(23名女性和10名男性)的自发性PTC，他们的平均年龄为18岁(范围6-21岁)，平均随访时间为3.5年(范围0-13.4年)。其中PTC-1突变8例(53%)，PTC-P突变2例(13%)，PTC-3突变2例(13%)，PTC联合突变3例(20%)。这一分布与报道的辐射诱发PTC儿童的分布有显著不同(P=0.001，经X~2分析)。Ret/PTC突变的存在或类型与患者的年龄、肿瘤大小、病灶、确诊时的疾病程度或复发无关。我们得出结论：ret/PTC突变在散发性儿童PTC中很常见，2)以PTC-1为主，3)经常是多发性的，4)与报道的放射性PTC的分布不同。
The ret/PTC rearrangements (PTC-1, PTC-3, and PTC-3) are characteristic of papillary thyroid cancer (PTC). In adults, PTC-1 is common and may be associated with an aggressive clinical course. The incidence and significance of ret/PTC mutations are less well understood in children. We examined spontaneous PTC from 33 patients (23 females and 10 males) with a median age of 18 yr (range, 6-21 yr) and a median follow-up of 3.5 yr (range, 0-13.4 yr). The ret/PTC mutations were identified in 15 tumors (45%), including 8 PTC-1 (8 of 15, 53%), 2 PTC-P (2 of 15, 13%), 2 PTC-3 (2 of 15, 13%), and 3 13 df 15, 20%) combined PTC mutations (PTC-1 and PTC-P). This distribution is significantly different (P = 0.001, by chi(2) analysis) from that reported for children with radiation-induced PTC. There was no correlation between the presence or type of ret/PTC mutation and patient age, tumor size, focality, extent of disease at diagnosis, or recurrence. We conclude that ret/PTC mutations are 1) common in sporadic childhood PTC, 2) predominantly PTC-1, 3) frequently multiple, and 4) of different distribution than that reported for children with radiation-induced PTC.