T2 mapping in myocardial disease: a comprehensive review.

T2 mapping in myocardial disease: a comprehensive review.
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心肌疾病中的T2映射:全面评论。

DOI:
10.1186/s12968-022-00866-0
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发表时间:
2022-06-06
影响因子:
6.4
通讯作者:
Zareba, Karolina M.
Zareba, Karolina M.
中科院分区:
医学2区
文献类型:
--
作者:
O'Brien, Aaron T.;Gil, Katarzyna E.;Varghese, Juliet;Simonetti, Orlando P.;Zareba, Karolina M.

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心血管磁共振(CMR)被认为是心肌组织表征的金标准成像方式。升高的横向松弛时间(T2)是特定于心肌水含量增加,自由水增加的特异性,并用作心肌水肿的指数。定量T2映射的优势在于心肌水肿的准确表征,以及在不使用造影剂或电离辐射的情况下早期检测可逆心肌疾病。定量T2映射克服了T2加权成像的局限性,以可靠评估弥漫性心肌水肿,可用于诊断,分期和监测心肌损伤。有力的证据支持在急性心肌梗死,心肌炎,心脏移植排斥和扩张心肌病中T2映射的临床使用。积累数据支持T2映射的实用性,以评估其他心肌病,流变学疾病,具有心脏参与以及监测与癌症治疗相关的心脏损伤。重要的是,升高的T2松弛时间可能是许多疾病中心肌损伤的第一个迹象,并且通常在症状之前,射血分数的变化和不可逆的心肌重塑。这项全面的综述讨论了心肌T2映射的技术考虑和临床作用,重点是扩大这种独特的无创组织参数的影响。
Cardiovascular magnetic resonance (CMR) is considered the gold standard imaging modality for myocardial tissue characterization. Elevated transverse relaxation time (T2) is specific for increased myocardial water content, increased free water, and is used as an index of myocardial edema. The strengths of quantitative T2 mapping lie in the accurate characterization of myocardial edema, and the early detection of reversible myocardial disease without the use of contrast agents or ionizing radiation. Quantitative T2 mapping overcomes the limitations of T2-weighted imaging for reliable assessment of diffuse myocardial edema and can be used to diagnose, stage, and monitor myocardial injury. Strong evidence supports the clinical use of T2 mapping in acute myocardial infarction, myocarditis, heart transplant rejection, and dilated cardiomyopathy. Accumulating data support the utility of T2 mapping for the assessment of other cardiomyopathies, rheumatologic conditions with cardiac involvement, and monitoring for cancer therapy-related cardiac injury. Importantly, elevated T2 relaxation time may be the first sign of myocardial injury in many diseases and oftentimes precedes symptoms, changes in ejection fraction, and irreversible myocardial remodeling. This comprehensive review discusses the technical considerations and clinical roles of myocardial T2 mapping with an emphasis on expanding the impact of this unique, noninvasive tissue parameter.
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