Age-related differences in recovery of blood flow and metabolism after cerebral ischemia in swine.
Age-related differences in recovery of blood flow and metabolism after cerebral ischemia in swine.
复制标题
猪脑缺血后血流和代谢恢复的年龄相关差异。
DOI：
10.1161/01.str.22.5.626
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发表时间：
1991
期刊：
影响因子：
8.3
通讯作者：
Traystman,RJ
中科院分区：
文献类型：
--
作者：
Ichord,RN;Kirsch,JR;Helfaer,MA;Haun,S;Traystman,RJ
我们测试了两个假设：1）完全缺血后，1-2 周龄仔猪的脑血流量、耗氧量和诱发电位在再灌注 120 分钟时比 6-10 月龄仔猪更完全恢复到缺血前值； 2)再灌注120分钟时，仔猪和猪的脑血流量、耗氧量和电功能的恢复在不完全缺血后比在完全缺血后更好。在颅内压升高引起的缺血30分钟内，微球技术测定的脑血流量在完全缺血时降至0-1ml/min/100g，在重度不完全缺血时降至1-10ml/min/100g，或在中度不完全缺血时降至10-20ml/min/100g。在完全缺血后的再灌注过程中，仔猪和猪都表现出充血，但猪的更多脑区出现延迟性低灌注，仔猪的耗氧量恢复到缺血前值，但仔猪没有恢复到缺血前值（缺血前值的70+/-10%），仔猪诱发电位恢复得比猪更好（分别为缺血前值的24+/-4%和9+/-4%）。与完全缺血相比，不完全缺血恢复期间，仔猪和猪的脑部充血和低灌注区域较少，耗氧量和电功能有所改善。我们推测，由于再灌注损伤减少，仔猪比猪更能耐受完全缺血，并且由于缺血期间底物供应改善，两组从不完全缺血中恢复得比完全缺血更好。
We tested two hypotheses: 1) that cerebral blood flow, oxygen consumption, and evoked potentials recover to preischemic values at 120 minutes of reperfusion more completely in 1-2-week-old piglets than in 6-10-month-old pigs after complete ischemia; and 2) that recovery of cerebral blood flow, oxygen consumption, and electrical function in piglets and pigs at 120 minutes of reperfusion is better after incomplete than after complete ischemia. During 30 minutes of ischemia produced by intracranial pressure elevation, cerebral blood flow determined by the microspheres technique was decreased to 0-1 ml/min/100 g with complete ischemia, to 1-10 ml/min/100 g with severe incomplete ischemia, or to 10-20 ml/min/100 g with moderate incomplete ischemia. During reperfusion after complete ischemia, both piglets and pigs demonstrated hyperemia but delayed hypoperfusion occurred in more brain regions in pigs, oxygen consumption returned to preischemic values in piglets but not in pigs (70 +/- 10% of preischemic values), and evoked potentials recovered better in piglets than in pigs (24 +/- 4% and 9 +/- 4% of preischemic values, respectively). Both piglets and pigs had fewer brain areas with hyperemia and hypoperfusion and improved oxygen consumption and electrical function during recovery from incomplete than from complete ischemia. We speculate that piglets tolerate complete ischemia better than pigs because of decreased reperfusion injury and that both groups recover better from incomplete than complete ischemia because of improved substrate supply during ischemia.