Fatty liver index is associated to pulse wave velocity in healthy subjects: Data from the Brisighella Heart Study
Fatty liver index is associated to pulse wave velocity in healthy subjects: Data from the Brisighella Heart Study
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DOI：
10.1016/j.ejim.2018.03.010
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发表时间：
2018-07-01
影响因子：
8
通讯作者：
Borghi, Claudio
中科院分区：
文献类型：
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作者：
Cicero, Arrigo F. G.;Gitto, Stefano;Borghi, Claudio
背景：非酒精性脂肪性肝病（NAFLD）与心血管疾病风险增加有关。我们的目的是评估脂肪肝的指标与动脉僵硬度（AS）的关联。方法：我们分析了在最后一次Brisighella调查访问的成年志愿者的数据。我们评估脉搏波传导速度（PWV）和以下非侵入性肝脏脂肪变性指标：脂肪肝指数（FLI）、脂质蓄积积（Lipid Accumulation Product，HSI）。我们根据非酒精性脂肪性肝炎（NASH）的风险对患者进行了比较：低风险（BMI < 28且无糖尿病），中风险（BMI >= 28或糖尿病），高风险（BMI >= 28且糖尿病）。多元线性回归分析评估AS的预测因素。结果：我们研究了1731名志愿者。在低代谢风险受试者中，HSI（RR = 0.138，95% CI 0.105-0.170，p < 0.001），FLI（RR = 0.024，95% CI 0.016-0.032，p < 0.001），（RR = 0.014，95% CI 0.008-0.020，p < 0.001）和血清尿酸（RR = 0.150，95% CI 0.024-0.275，p = 0.019）是AS的显著预测因子。HSI和FLI是中度危险组PWV的预测因子（RR = 0.116，95% CI 0.071-0.160，p < 0.001; RR = 0.010，95% CI 0.001-0.020，p = 0.041）。在高危人群中，FLI和尿酸与PWV相关（RR = 0.049，95%CI0.011 -0.087，p = 0.013; RR = 0.632，95%CI0.222 -1.041，p = 0.003）。
Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is associated to increased risk of cardiovascular disease. Our aim was to evaluate association of indexes of fatty liver with arterial stiffness (AS).Methods: We analyzed data of adult volunteers visited during the last Brisighella survey. We evaluated the Pulse Wave Velocity (PWV) and the following non-invasive indexes of liver steatosis: Fatty Liver Index (FLI), Lipid Accumulation Product (LAP), Hepatic Steatosis Index (HSI). We compared patients according to the risk of NonAlcoholic Steatohepatitis (NASH): low-risk (BMI < 28 and no diabetes), intermediate-risk (BMI >= 28 or diabetes), high-risk (BMI >= 28 and diabetes). Multiple Linear Regression analysis was assessed for predictors of AS.Results: We studied 1731 volunteers. In subjects with low metabolic risk, HSI (RR = 0.138, 95% CI 0.105-0.170, p < 0.001), FLI (RR = 0.024, 95% CI 0.016-0.032, p < 0.001), LAP (RR = 0.014, 95% CI 0.008-0.020, p < 0.001) and Serum Uric Acid (RR = 0.150, 95% CI 0.024-0.275, p = 0.019) were significant predictors of AS. HSI and FLI emerged as predictors of PWV in intermediate risk group (RR = 0.116, 95% CI 0.071-0.160, p < 0.001; RR = 0.010, 95% CI 0.001-0.020, p = 0.041). In volunteers with high risk, FLI and Uric Acid were related to PWV (RR = 0.049, 95% CI 0.011-0.087, p = 0.013; RR = 0.632, 95% CI 0.222-1.041, p = 0.003).Conclusion: Fatty liver indirect indexes were associated to AS in subjects with different metabolic risk profiles.