Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model.
Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model.
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DOI：
10.1016/j.ijrobp.2021.09.005
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发表时间：
2022-02-01
期刊：
影响因子：
--
通讯作者：
Waleed Gaber M
中科院分区：
文献类型：
--
作者：
Tang TT;Zawaski JA;Kesler S;Beamish CA;Inoue T;Perez EC;Bronk L;Poenisch F;Briere TM;Sabek OM;Grosshans DR;Waleed Gaber M
与光子头部放射治疗(X-CRT)相比，质子头部放射治疗(P-CRT)在减少儿童脑肿瘤放射后遗症方面具有潜在的优势。本研究旨在确定认知、功能磁共振和正电子发射断层扫描成像标志物和分子放射模式之间的差异。幼年大鼠接受6MVX-CRT或100MeVP-CRT束中展布喇格峰处单次照射10GY(相对生物效应−加权剂量)。在CRT后3、6和12个月，采用5选择系列反应时任务评估执行功能。术后12个月行18F-氟代脱氧葡萄糖正电子发射断层扫描和功能性体外磁共振成像，并对神经炎症标志物进行染色。与假手术组相比，照射组大鼠认知功能受损，遗漏次数增加，错误反应和早熟反应减少(P≤.05)。X-CRT的准确性低于Sham(P≤.001)。在不同放射方式之间，认知改变率没有发现显著差异。在CRT后12个月，X-CRT组的葡萄糖代谢显著高于Sham组(P=0.04)，而P-CRT组则不明显。使用扩散张量成像，P-CRT脑内白质体积和纤维长度比假手术组大(P<；.03)。仅X-CRT动物的表观弥散系数值高于假手术组(P=0.04)。与X-CRT相比，P-CRT动物有更多的连接性改变。相关分析确定了几个与认知表现有关的成像特征。此外，小胶质细胞增多症(P<；.05)、星形胶质细胞增多症(P<；.01)和髓鞘变薄(P<；.05)在两种放射治疗方式中均可观察到，X-CRT显示炎症稍多。与假手术组相比，P-CRT和X-CRT均可引起神经认知功能改变。虽然照射组之间在神经炎症方面没有显著差异，但在晚期糖代谢和脑连接体方面发现了差异。我们的结果表明，尽管质子剂量的相对生物效应加权，但仍然存在差异效应，值得进一步研究。
Compared with photon cranial radiation therapy (X-CRT), proton cranial radiation therapy (P-CRT) offers potential advantages in limiting radiation-induced sequalae in the treatment of pediatric brain tumors. This study aims to identify cognitive, functional magnetic resonance and positron emission tomography imaging markers and molecular differences between the radiation modalities. Juvenile rats received a single faction of 10 Gy (relative biological effectiveness−weighted dose) delivered with 6 MV X-CRT or at the midspread out Bragg peak of a 100 MeV P-CRT beam. At 3, 6, and 12 months post-CRT, executive function was measured using 5-choice serial reaction time task. At ~12 months post-CRT, animals were imaged with 18F-Flurodeoxy-glucose positron emission tomography imaging followed by functional ex vivo magnetic resonance imaging and stained for markers of neuroinflammation. Irradiated animals had cognitive impairment with a higher number of omissions and lower incorrect and premature responses compared with sham (P ≤ .05). The accuracy of the animals’ X-CRT was less than that of sham (P ≤ .001). No significant difference in rates of cognitive change were found between the radiation modalities. At 12 months post-CRT, glucose metabolism was significantly higher than sham in X-CRT (P = .04) but not P-CRT. Using diffusion tensor imaging, P-CRT brains were found to have higher white matter volume and fiber lengths compared with sham (P < .03). Only X-CRT animals had higher apparent diffusion coefficient values compared with sham (P = .04). P-CRT animals had more connectomic changes compared with X-CRT. Correlative analysis identified several imaging features with cognitive performance. Further-more, microgliosis (P < .05), astrogliosis (P < .01), and myelin thinning (P <.05) were observed in both radiation modalities, with X-CRT showing slightly more inflammation. Both P-CRT and X-CRT lead to neurocognitive changes compared with sham. Although no significant difference was observed in neuroinflammation between the irradiated groups, differences were found in late-term glucose metabolism and brain connectome. Our results indicate that despite relative biological effectiveness weighting of the proton dose there are still differential effects which warrants further investigation.
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影响因子：
12.7
作者：
Ramaswamy V;Remke M;Bouffet E;Bailey S;Clifford SC;Doz F;Kool M;Dufour C;Vassal G;Milde T;Witt O;von Hoff K;Pietsch T;Northcott PA;Gajjar A;Robinson GW;Padovani L;André N;Massimino M;Pizer B;Packer R;Rutkowski S;Pfister SM;Taylor MD;Pomeroy SL
通讯作者：
Pomeroy SL
影响因子：
15.9
作者：
Reddick, WE;Glass, JO;Mulhern, RK
通讯作者：
Mulhern, RK
DOI：
10.1111/j.1749-6632.2010.05888.x
发表时间：
2011-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE
影响因子：
--
作者：
Sporns, Olaf
通讯作者：
Sporns, Olaf
影响因子：
3.1
作者：
Bronk, Julianna K.;Guha-Thakurta, Nandita;McGovern, Susan L.
通讯作者：
McGovern, Susan L.
影响因子：
45.3
作者：
Kahalley, Lisa S.;Peterson, Rachel;Mabbott, Donald
通讯作者：
Mabbott, Donald