Salivary Stress Markers, Stress, and Periodontitis: A Pilot Study
Salivary Stress Markers, Stress, and Periodontitis: A Pilot Study
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唾液压力标记物、压力和牙周炎： 一项试点研究
DOI：
10.1902/jop.2010.100319
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发表时间：
2011-02-01
影响因子：
4.3
通讯作者：
Jacobs, Reinhilde
中科院分区：
文献类型：
--
作者：
Rai, Balwant;Kaur, Jasdeep;Jacobs, Reinhilde
背景：一些横断面和纵向研究试图将牙周炎与压力联系起来。据我们所知，只有一个小的研究发表的机制，压力可能会影响牙周病，提出行为和生理机制，并调查炎症作为一个潜在的调解人的作用。本研究计划探讨牙周病，心理因素，和唾液标志物的压力，心理神经免疫变量，和健康behaviors.Methods：100牙周炎患者之间的关联被选中，参与者提供的一般健康，慢性压力和人口统计学信息。从唾液中测量压力标记物（choromogranin A，皮质醇，α-淀粉酶和β-内啡肽）。牙医评估舌面和颊面上的牙菌斑的存在，牙龈指数，和剩余的牙齿与牙周diseases.Results的数量：应力和唾液应力标记物与牙周病的临床参数显着相关（范围从0.19到0.59，P < 0.001）。在压力下忽视刷牙与牙齿缺失有关。调整压力变量后，唾液皮质醇和β-内啡肽与牙齿脱落和牙周临床参数显著相关（P
Background: Some cross-sectional and longitudinal studies attempted to link periodontitis with stress. To our knowledge, only one small study was published on the mechanism by which stress may influence periodontal diseases, suggesting behavioral and physiologic mechanisms and investigating the role of inflammation as a potential mediator. The present study is planned to explore the associations among periodontal disease, psychologic factors, and salivary markers of stress, psychoneuroimmunologic variables, and health behaviors.Methods: One hundred periodontitis patients were selected, and participants provided information on general health, chronic stress, and demographics. Stress markers (choromogranin A, cortisol, alpha-amylase, and beta-endorphin) were measured from saliva. A dentist assessed the presence of dental plaque on lingual and buccal surfaces, the gingival index, and the number of remaining teeth with periodontal disease.Results: Stress and salivary stress markers were significantly correlated with clinical parameters of periodontal disease (ranging from 0.19 to 0.59; P < 0.001). Neglecting to brush teeth during stress was associated with missing teeth. After adjusting for stress variables, salivary cortisol and beta-endorphin were significantly associated with tooth loss and periodontal clinical parameters (P