Modulation of pain sensation by stress-related testosterone and cortisol
Modulation of pain sensation by stress-related testosterone and cortisol
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DOI：
10.1111/j.1365-2044.2012.07267.x
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发表时间：
2012-10-01
期刊：
影响因子：
10.7
通讯作者：
Lee, Y. D.
中科院分区：
文献类型：
--
作者：
Choi, J. C.;Chung, M. I.;Lee, Y. D.
压力会增加皮质醇，减少睾丸激素。目前尚不清楚疼痛是否受到与压力有关的睾丸激素的影响。因此，我们研究了压力是否可以通过降低睾酮和增加皮质醇来影响疼痛感知。疼痛阈值，疼痛和焦虑的评级和唾液睾酮和皮质醇水平在46名健康男性在休息和压力条件下进行了测量。疼痛是由电刺激引起的。压力是通过让参与者进行医学测试而引起的。压力显着增加焦虑等级和唾液皮质醇水平，但降低唾液睾酮水平。压力也增加了疼痛等级，降低了疼痛阈值。在应激过程中，皮质醇水平与痛阈呈负相关，睾酮水平与痛阈呈正相关。结果表明，睾酮可以减少和皮质醇可以增加由电刺激引起的疼痛，这表明急性临床疼痛可以通过控制应激和管理随之而来的应激相关的睾酮和皮质醇来缓解。
Stress increases cortisol and decreases testosterone. It is not known whether pain is affected by stress-related testosterone. Therefore, we investigated whether stress can affect pain perception by decreasing testosterone and increasing cortisol. Pain thresholds, pain and anxiety ratings and salivary testosterone and cortisol levels were measured in 46 healthy men during resting and stressful conditions. Pain was induced by electrical stimulation. Stress was induced by having participants perform a medical test. Stress significantly increased anxiety ratings and salivary cortisol levels, but decreased salivary testosterone levels. Stress also increased pain ratings and decreased pain thresholds. During stress, cortisol levels were negatively correlated with pain thresholds and testosterone levels were positively correlated with pain thresholds. Results indicated that testosterone can decrease and cortisol can increase pain induced by electrical stimulation, suggesting that acute clinical pain may be relieved by controlling stress and managing consequent stress-related testosterone and cortisol.