Electrically stimulated axon reflexes are diminished in diabetic small fiber neuropathies
Electrically stimulated axon reflexes are diminished in diabetic small fiber neuropathies
复制标题
DOI：
10.2337/diabetes.53.3.769
复制
发表时间：
2004-03-01
期刊：
影响因子：
7.7
通讯作者：
Bickel, A
中科院分区：
文献类型：
--
作者：
Krämer, HH;Schmelz, M;Bickel, A
轴突反射介导的耀斑取决于皮肤c纤维的密度和功能，并可能在糖尿病神经病变中受损。采用皮内电刺激诱导神经源性轴突反射耀斑，并用激光多普勒成像（LDI）分析足背和大腿腹侧耀斑的大小和强度。我们调查了12例伴有小纤维神经病变（SFNs）的糖尿病患者、5例无神经病变的糖尿病患者和14例健康对照。其中5名正常受试者在12个月后重新接受评估。在将SFN患者与对照组进行比较时，我们发现足部SFN耀斑大小而非血管舒张强度（通量）降低(P
Axon reflex mediated flare depends on the density and the function of cutaneous C-fibers and may be impaired in diabetic neuropathy. We induced neurogenic axon reflex flare by intracutaneous electrical stimulation and analyzed size and intensity of the flare on the dorsum of the foot and ventral thigh with laser Doppler imaging (LDI). We investigated 12 diabetic subjects with small fiber neuropathies (SFNs), 5 diabetic subjects without neuropathy (NO-Ns), and 14 healthy control subjects. Five of the normal subjects were reassessed after 12 months. In comparing patients with SFN to control subjects, we found that SFN flare size but not the intensity of vasodilation (flux) was reduced on the feet (P