Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements
Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements
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DOI：
10.1016/j.modgep.2004.01.016
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发表时间：
2004-09-01
影响因子：
1.2
通讯作者：
Fisher, S
中科院分区：
文献类型：
--
作者：
Flores, MV;Tsang, VWK;Fisher, S
脊椎动物骨骼中细胞的分化是由精确的遗传程序控制的。该途径中的一个关键调控基因编码转录因子Runx2，其在小鼠中是所有成骨细胞分化和肥大软骨细胞亚群正常发育所需的。为了探索模式生物斑马鱼（Danio rerio）中骨骼发生细胞的分化，我们已经确定了哺乳动物基因runx2a和runx2b的两个直系同源物。这两个基因与哺乳动物基因共享序列同源性和基因结构，并映射到斑马鱼基因组中与人类基因所在区域显示保守共线性的区域。虽然这两个基因在发育中的骨骼元素中表达，但它们在表达模式上显示出部分分歧的证据，这可能解释了为什么这两个直向同源物在硬骨鱼进化中被保留下来。(C)2004 Elsevier B.V.保留所有权利。
The differentiation of cells in the vertebrate skeleton is controlled by a precise genetic program. One crucial regulatory gene in the pathway encodes the transcription factor Runx2, which in mouse is required for differentiation of all osteoblasts and the proper development of a subset of hypertrophic chondrocytes. To explore the differentiation of skeletogenic cells in the model organism zebrafish (Danio rerio), we have identified two orthologues of the mammalian gene, runx2a and runx2b. Both genes share sequence homology and gene structure with the mammalian genes, and map to regions of the zebrafish genome displaying conserved synteny with the region where the human gene is localized. While both genes are expressed in developing skeletal elements, they show evidence of partial divergence in expression pattern, possibly explaining why both orthologues have been retained through teleost evolution. (C) 2004 Elsevier B.V. All rights reserved.