STIMULUS: Noninvasive Dynamic Patterns of Neurostimulation Using Spatio-Temporal Interference
STIMULUS: Noninvasive Dynamic Patterns of Neurostimulation Using Spatio-Temporal Interference
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DOI：
10.1109/tbme.2019.2919912
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发表时间：
2020-03-01
影响因子：
4.6
通讯作者：
Grover, Pulkit
中科院分区：
文献类型：
--
作者：
Cao, Jiaming;Grover, Pulkit
目的：本文获得了利用电流实现空间精确的无创深部脑刺激的策略。方法：我们提供基于时空干扰的刺激聚焦策略（STIMULUS），该策略可生成丰富的时空干扰电流模式，以精确、深入地刺激大脑内部。为了校准和比较使用不同技术的刺激的准确性，我们利用神经元的计算霍奇金-赫胥黎型模型和头部电流分散模型。结果：在此计算模型中，STIMULUS 在空间精度方面显着优于最近提出的时间干扰 (TI) 刺激策略。我们的结果还表明，STIMULUS 可以实现可操纵的多部位刺激，这对于在脑机接口中提供反馈非常重要。最后，通过检查更多的哺乳动物神经元类型，我们还观察到并非每个神经元都表现出时间干扰刺激。结论：计算机模拟表明，所提出的刺激策略有潜力实现具有高空间精度的无创深部脑刺激，并且具有生成丰富刺激模式的灵活性。某些神经元类型不表现出 TI 刺激这一事实表明，在评估 TI 刺激在大型哺乳动物大脑中的应用结论时需要谨慎。意义：一种可靠、无创且精确地刺激人脑深处的技术可能会彻底改变人类神经科学和临床治疗。我们获得了最近提出的 TI 刺激的第一个计算演示。在此基础上，我们提出了一种新颖的策略，可以高精度和灵活地进行刺激。
Objective: This paper obtains strategies that can achieve spatially precise noninvasive deep brain stimulation using electrical currents. Methods: We provide the Spatio-Temporal Interference-based stiMULation focUsing Strategy (STIMULUS) that generates rich patterns of spatiotemporally interfering currents to stimulate precisely and deep inside the brain. To calibrate and compare the accuracy of stimulation using different techniques, we utilize computational Hodgkin-Huxley-type models for neurons and a model of current dispersion in the head. Results: In this computational model, STIMULUS dramatically outperforms the recently proposed Temporal Interference (TI) stimulation strategy in spatial precision. Our results also suggest that STIMULUS can attain steerable and multisite stimulation, which can be important in giving feedback in brain-machine interfaces. Finally, by examining more mammalian neuron types, we also observe that not every neuron exhibits temporal-interference stimulation. Conclusions: Computer simulations suggest that the proposed STIMULUS strategy has potential to achieve noninvasive electrical deep brain stimulation with high spatial precision and, further, has the flexibility of generating rich stimulation patterns. The fact that some neuron types do not exhibit TI stimulation suggests that caution is needed in evaluating conclusions of application of TI stimulation on large mammalian brains. Significance: A technique to reliably, noninvasively, and precisely stimulate deep inside the human brain could revolutionize human neuroscience and clinical treatments. We obtain the first computational demonstration of the recently proposed TI stimulation. Advancing on that, we propose a novel strategy that can perform stimulation with high precision and flexibility.