Intracranial Artery Calcification and Its Clinical Significance.
Intracranial Artery Calcification and Its Clinical Significance.
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颅内动脉钙化及其临床意义
DOI：
10.3988/jcn.2016.12.3.253
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Wong KS
中科院分区：
文献类型：
--
作者：
Wu XH;Chen XY;Wang LJ;Wong KS
在头颅CT平扫中，颅内动脉钙化(IAC)是一种很容易识别的实体。最近的研究发现，IAC在世界范围内的患病率很高，这可能与缺血性中风和认知能力下降有关。衰老、传统的心血管危险因素和慢性肾脏疾病已被发现与IAC有关。可以使用不同的视觉分级标准或各种定量方法(通过测量体积或强度)来评估IAC的严重程度。迫切需要一种使用一致标准评估IAC的客观方法，以促进涉及不同人群的多项研究之间的比较。越来越多的临床研究表明，IAC可以作为颅内动脉粥样硬化的指标。然而，IAC与缺血性卒中潜在相关性的病理生理学基础--通过直接动脉狭窄或斑块稳定--仍有待确定。需要更多精心设计的临床研究来探索IAC在血管事件中的预测价值和潜在的病理生理机制。
Intracranial arterial calcification (IAC) is an easily identifiable entity on plain head computed tomography scans. Recent studies have found high prevalence rates for IAC worldwide, and this may be associated with ischemic stroke and cognitive decline. Aging, traditional cardiovascular risk factors, and chronic kidney disease have been found to be associated with IAC. The severity of IAC can be assessed using different visual grading scales or various quantitative methods (by measuring volume or intensity). An objective method for assessing IAC using consistent criteria is urgently required to facilitate comparisons between multiple studies involving diverse populations. There is accumulating evidence from clinical studies that IAC could be utilized as an indicator of intracranial atherosclerosis. However, the pathophysiology underlying the potential correlation between IAC and ischemic stroke—through direct arterial stenosis or plaque stability—remains to be determined. More well-designed clinical studies are needed to explore the predictive values of IAC in vascular events and the underlying pathophysiological mechanisms.