Pancreatic cancer and its stroma: A conspiracy theory
Pancreatic cancer and its stroma: A conspiracy theory
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DOI：
10.3748/wjg.v20.i32.11216
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发表时间：
2014-08-28
影响因子：
4.3
通讯作者：
Apte, Minoti V.
中科院分区：
文献类型：
--
作者：
Xu, Zhihong;Pothula, Srinivasa P.;Apte, Minoti V.
胰腺癌的特征是突出的促纤维增生/间质反应，直到最近才受到关注。鉴于几十年来仅关注胰腺癌细胞的治疗未能显著改善患者的预后，研究工作现在已经转向了解基质反应的病理生理学及其在癌症进展中的作用。在这方面，我们的小组是第一个鉴定出产生胰腺癌胶原基质的细胞（胰腺星状细胞，PSC），并证明这些细胞与癌细胞密切相互作用，以促进局部肿瘤生长和远处转移。越来越多的证据表明，间质PSC也可能介导血管生成、免疫逃避以及众所周知的胰腺癌对化疗和放疗的抗性。这篇综述将总结目前关于胰腺星状细胞和间质在胰腺癌生物学中的关键作用的知识，以及正在开发的靶向间质的治疗方法，以改善这种毁灭性疾病的结果。(C)2014百世登出版集团股份有限公司All rights reserved.
Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has received little attention until recent times. Given that treatments focusing on pancreatic cancer cells alone have failed to significantly improve patient outcome over many decades, research efforts have now moved to understanding the pathophysiology of the stromal reaction and its role in cancer progression. In this regard, our Group was the first to identify the cells (pancreatic stellate cells, PSCs) that produced the collagenous stroma of pancreatic cancer and to demonstrate that these cells interacted closely with cancer cells to facilitate local tumour growth and distant metastasis. Evidence is accumulating to indicate that stromal PSCs may also mediate angiogenesis, immune evasion and the well known resistance of pancreatic cancer to chemotherapy and radiotherapy. This review will summarise current knowledge regarding the critical role of pancreatic stellate cells and the stroma in pancreatic cancer biology and the therapeutic approaches being developed to target the stroma in a bid to improve the outcome of this devastating disease. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.